2-Pyridinecarbonitrile,3-amino-6-ethoxy-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarbonitrile,3-amino-6-ethoxy-(9CI)
• CAS No.: 625822-19-7
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.179
• Mol file: 625822-19-7.mol

Synonyms:2-Pyridinecarbonitrile,3-amino-6-ethoxy-(9CI)

Chemical Property of 2-Pyridinecarbonitrile,3-amino-6-ethoxy-(9CI)

Chemical Property:

• PSA: 71.93000
• LogP: 1.51538

Purity/Quality:

3-Amino-2-cyano-6-ethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinecarbonitrile,3-amino-6-ethoxy-(9CI)

There total 4 articles about 2-Pyridinecarbonitrile,3-amino-6-ethoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

zinc(II) cyanide (557-21-1) + 3-amino-2-bromo-6-ethoxypyridine → 3-amino-6-ethoxypyridine-2-carbonitrile (625822-19-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1021/op0341061

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 3-amino-6-ethoxypyridine-2-carbonitrile (625822-19-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / Inert atmosphere

2: iron; calcium chloride / ethanol / Inert atmosphere

3: acetic acid; sodium acetate; bromine / 1.17 h / 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium acetate; iron; acetic acid; calcium chloride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/op0341061

Reference yield:

5-amino-2-ethoxypyridine (52025-34-0) → 3-amino-6-ethoxypyridine-2-carbonitrile (625822-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; sodium acetate; bromine / 1.17 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium acetate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/op0341061

upstream raw materials:

zinc(II) cyanide

2-chloro-5-nitropyridine

5-amino-2-ethoxypyridine

2-ethoxy-5-nitropyridine