Pyrimidine-2-sulfonamide

Base Information

• Chemical Name: Pyrimidine-2-sulfonamide
• CAS No.: 142047-90-3
• Molecular Formula: C4H5 N3 O2 S
• Molecular Weight: 159.169
• European Community (EC) Number: 894-490-0
• ChEMBL ID: CHEMBL4528470
• DSSTox Substance ID: DTXSID40595001
• Wikidata: Q82489932
• Mol file: 142047-90-3.mol

Synonyms:pyrimidine-2-sulfonamide;142047-90-3;2-Pyrimidinesulfonamide;2-Pyrimidinesulfonamide(9CI);pyrimidyl-sulfonamide;pyrimidine sulfonamide;SCHEMBL51141;CHEMBL4528470;DTXSID40595001;WJJBIYLGJUVNJX-UHFFFAOYSA-N;AKOS010995687;AM98028;SB56998;DB-261428;EN300-85716;Z854066844

Chemical Property of Pyrimidine-2-sulfonamide

Chemical Property:

• PSA: 94.32000
• LogP: 0.90510
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 159.01024758
• Heavy Atom Count: 10
• Complexity: 189

Purity/Quality:

97% ^*data from raw suppliers

pyrimidine-2-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(N=C1)S(=O)(=O)N

Technology Process of Pyrimidine-2-sulfonamide

There total 5 articles about Pyrimidine-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2-sulfanylpyrimidine (131242-36-9) → pyrimidine-2-sulfonamide (142047-90-3)

Guidance literature:

2-sulfanylpyrimidine; With hydrogenchloride; sodium hypochlorite; In dichloromethane; water; at 0 ℃; for 0.25h;

With ammonia; In dichloromethane; at -70 - 20 ℃; for 16.25h;

Reference yield:

2,6-Dichloroaniline (608-31-1) → pyrimidine-2-sulfonamide (142047-90-3) + N-(2,6-dichlorophenyl)-4,6-dimethoxy-2-pyrimidinesulfonamide

Guidance literature:

Reference yield:

pyrimidine-2-sulfonyl chloride → pyrimidine-2-sulfonamide (142047-90-3)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 0 - 20 ℃; for 1h;

upstream raw materials:

2-thioxopyrimidine

2,6-Dichloroaniline

2-sulfanylpyrimidine