(S)-2-FLUOROBENZHYDROL

Base Information

• Chemical Name: (S)-2-FLUOROBENZHYDROL
• CAS No.: 146324-43-8
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.228
• Hs Code.: 2906299090
• Mol file: 146324-43-8.mol

Synonyms:Benzenemethanol,2-fluoro-a-phenyl-, (S)-; (aS)-(+)-2-Fluoro-a-phenylbenzenemethanol

Chemical Property of (S)-2-FLUOROBENZHYDROL

Chemical Property:

• Refractive Index: 1.581
• Boiling Point: 312.3°Cat760mmHg
• Flash Point: 172.6°C
• PSA: 20.23000
• Density: 1.18g/cm³
• LogP: 2.90740

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-2-FLUOROBENZHYDROL 98.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-FLUOROBENZHYDROL

There total 28 articles about (S)-2-FLUOROBENZHYDROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

o-fluorobenzophenone (342-24-5) → (S)-(2-fluorophenyl)(phenyl)methanol (362-54-9,143880-81-3,146324-43-8)

Guidance literature:

With trans-RuCl₂[(S)-xylbinap][(S)-daipen]; potassium tert-butylate; hydrogen; In isopropyl alcohol; tert-butyl alcohol; at 28 ℃; for 14h; under 6080.41 Torr;

DOI:10.1021/ol9904139

Reference yield: 99.0%

o-fluorobenzophenone (342-24-5) → (R)-(+)-(2-fluorophenyl)(phenyl)methanol (362-54-9,146324-43-8,143880-81-3) + (S)-(2-fluorophenyl)(phenyl)methanol (362-54-9,143880-81-3,146324-43-8)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₄₃H₅₃FeN₂O₂PS; hydrogen; lithium tert-butoxide; In isopropyl alcohol; at 25 - 30 ℃; for 12h; under 22801.5 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.joc.8b01276

Reference yield: 99.0%

o-fluorobenzophenone (342-24-5) → (R)-(+)-(2-fluorophenyl)(phenyl)methanol (362-54-9,146324-43-8,143880-81-3) + (S)-(2-fluorophenyl)(phenyl)methanol (362-54-9,143880-81-3,146324-43-8)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₄₃H₅₃FeN₂O₂PS; hydrogen; lithium tert-butoxide; In isopropyl alcohol; at 25 - 30 ℃; for 12h; under 22801.5 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.joc.8b01276

upstream raw materials:

o-fluorobenzophenone

2-Fluorobenzaldehyde

phenylboronic acid

diphenylzinc