342-24-5

Usage

Chemical Properties

clear slightly yellow to yellow liquid

InChI:InChI=1/C8H7FO/c1-6(10)7-4-2-3-5-8(7)9/h2-5H,1H3

Upstream product

• 424-79-3 1,2-bis-(2-fluoro-phenyl)-1,2-diphenyl-ethane-1,2-diol 
• 103-73-1 Phenetole 
• 393-52-2 2-Fluorobenzoyl chloride 
• 128254-29-5 (2-Fluoro-4-trimethylsilanyl-phenyl)-phenyl-methanone 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 98-88-4 benzoyl chloride 
• 934-56-5 trimethyl(phenyl)stannane 
• 587-85-9 diphenylmercury(II) 
• 71-43-2 benzene 
• 462-06-6 fluorobenzene 
• 100-47-0 benzonitrile 
• 119-61-9 benzophenone 
• 128254-27-3 2-Fluoro-1,4-bis-trimethylsilanyl-benzene 
• 445-29-4 o-fluoro-benzoic acid 

Downstream Products

• 389-42-4 1-fluoro-2-(1-phenylethenyl)benzene 
• 339-10-6 1-(2-fluorophenyl)-1-phenylethan-1-ol 
• 3828-52-2 1-(2-fluoro-phenyl)-1,2-diphenyl-ethene 
• 56431-03-9 2-fluoro-α-vinyl-benzhydrol 
• 56431-10-8 2-Fluoro-α-ethyl-benzhydrol 
• 55317-39-0 (2-(1H-pyrazol-1-yl)phenyl)(phenyl)methanone 
• 72419-06-8 4-phenyl-4H-pyrazolo[1,5-a]indol-4-ol 
• 138479-66-0 9-phenyl-9H-imidazo<1,2-a>indol-9-ol 
• 65611-36-1 2-(imidazol-1'-yl)benzophenone 
• 138479-67-1 2-(1',2',3'-triazol-1'-yl)benzophenone 
• 138479-68-2 [2-(2H-1,2,3-triazol-2-yl)phenyl](phenyl)methanone 
• 138479-69-3 4-phenyl-4H-<1,2,3>triazolo<1,5-a>indol-4-ol 
• 138479-64-8 2-(1',2',4'-triazol-1'-yl)benzophenone 
• 138479-65-9 9-phenyl-9H-<1,2,4>triazolo<1,5-a>indol-9-ol 

Relevant academic research and scientific papers

Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N?C Cleavage

Although cross-coupling reactions of amides by selective N?C cleavage are one of the most powerful and burgeoning areas in organic synthesis due to the ubiquity of amide bonds, the development of mechanochemical, solid-state methods remains a major challe

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

Tetra- And Dinuclear Palladium Complexes Based on a Ligand of 2,8-Di-2-pyridinylanthyridine: Preparation, Characterization, and Catalytic Activity

Complexation of L [L = 5-phenyl-2,8-di-2-pyridinyl-anthyridine] with [Pd(CH3CN)4](BF4)2 and [Pd(CH3CN)3Cl](BF4) in a molar ratio of 1:2 rendered the corresponding dinuclear complexes [Pd2L (CH3CN)4](BF4)4 (1) and [Pd2L (CH3CN)2Cl2](BF4)2 (2), respectively. However, treatment of L with (COD)PdCl2 followed by anion exchange yielded a tetranuclear complex [Pd4L3Cl4](PF6)4(4a). Structures of these complexes are characterized by both spectroscopy and X-ray crystallography. Interconversion of these three complexes was studied via the manipulation of stoichiometric ratio of ligand to metal precursor. The catalytic activity of these complexes for carbonylative Suzuki-Miyaura cross-coupling was investigated. Complex 2 shows an excellent catalytic activity on the reaction of aryl iodide with arylboronic acid in the presence of atmospheric pressure of CO to give the corresponding benzophenones.

Preparation method of benzophenone derivative

The invention provides a preparation method of a benzophenone derivative. The preparation method comprises the following step: subjecting a benzoic acid compound as shown in a formula I, a trichlorotoluene compound as shown in a formula II and a benzene compound as shown in a formula III to reacting under the catalysis of Fe2O3 to obtain the benzophenone derivative. According to the preparation method provided by the invention, the metal oxide Fe2O3 with higher stability and safety is used as a catalyst, so corrosion of materials to equipment is avoided, and the preparation method is more environment-friendly; according to the preparation method, the target product is obtained through one-step reaction, reaction conditions are mild, and a process is simple; and the main byproduct benzoic acid compound generated by the reaction can be recycled by washing, extracting and desolventizing in post-treatment, and then is used as a reaction raw material for preparing the benzophenone derivative again, so wastewater treatment cost is reduced, and resources are fully utilized.

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

Transition Metal Catalyst-Free, Base-Promoted 1,2-Additions of Polyfluorophenylboronates to Aldehydes and Ketones

A novel protocol for the transition metal-free 1,2-addition of polyfluoroaryl boronate esters to aldehydes and ketones is reported, which provides secondary alcohols, tertiary alcohols, and ketones. Control experiments and DFT calculations indicate that both the ortho-F substituents on the polyfluorophenyl boronates and the counterion K+ in the carbonate base are critical. The distinguishing features of this procedure include the employment of commercially available starting materials and the broad scope of the reaction with a wide variety of carbonyl compounds giving moderate to excellent yields. Intriguing structural features involving O?H???O and O?H???N hydrogen bonding, as well as arene-perfluoroarene interactions, in this series of racemic polyfluoroaryl carbinols have also been addressed.

Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen

A simple, and practical oxidative scission of aromatic olefins to carbonyl compounds using O2as the sole oxidant with poly(ethylene glycol) dimethyl ether as a benign solvent has been developed. A wide range of monosubstituted,gem-disubstituted, 1,2-disubstituted, trisubstituted and tetrasubstituted aromatic olefins was successfully converted into the corresponding aldehydes and ketones in excellent yields even with gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.

Method for preparing aldehyde ketone compound through olefin oxidation

The invention provides a method for preparing an aldehyde ketone compound by olefin oxidation, which relates to an olefin oxidative cracking reaction in which oxygen participates. The method comprises the following specific steps: in the presence of a solvent and an oxidant, carrying out oxidative cracking on an olefin raw material to obtain a corresponding aldehyde ketone product. Compared with the traditional method, the method does not need to add any catalyst or ligand, does not need to use high-pressure oxygen, has the advantages of simple and mild reaction conditions, environment friendliness, low cost, high atom economy and the like, is wide in substrate application range and high in yield, and has a wide application prospect in the aspects of synthesis of aldehyde ketone medical intermediates and chemical raw materials.

Fe-S Catalyst Generated in Situ from Fe(III)- And S3?--Promoted Aerobic Oxidation of Terminal Alkenes

An iron-sulfur complex formed by the simple mixture of FeCl3 with S3?- generated in situ from K2S is developed and applied to selective aerobic oxidation of terminal alkenes. The reaction was carried out under an atmosphere of O2 (balloon) and could proceed on a gram scale, expanding the application of S3?- in organic synthesis. This study also encourages us to explore the application of an Fe-S catalyst in organic reactions.

Photo-induced oxidative cleavage of C-C double bonds for the synthesis of biaryl methanoneviaCeCl3catalysis

A Ce-catalyzed strategy is developed to produce biaryl methanonesviaphotooxidative cleavage of C-C double bonds at room temperature. This reaction is performed under air and demonstrates high activity as well as functional group tolerance. A synergistic Ce/ROH catalytic mechanism is also proposed based on the experimental observations. This protocol should be the first successful Ce-catalyzed photooxidation reaction of olefins with air as the oxidant, which would provide inspiration for the development of novel Ce-catalyzed photochemical synthesis processes.