TERT-BUTYL CIS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL CIS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE
• CAS No.: 142733-64-0
• Molecular Formula: C10H19 N O3
• Molecular Weight: 201.266
• Hs Code.: 2924299090
• Mol file: 142733-64-0.mol

Synonyms:Carbamicacid, [3-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester, cis- (9CI);cis-3-(tert-Butoxycarbonylamino)cyclobutanemethanol

Chemical Property of TERT-BUTYL CIS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE

Chemical Property:

• Vapor Pressure: 3.11E-05mmHg at 25°C
• Refractive Index: 1.486
• Boiling Point: 317.9°C at 760 mmHg
• PKA: 12.42±0.40(Predicted)
• Flash Point: 146.1°C
• PSA: 58.56000
• Density: 1.08g/cm³
• LogP: 1.67290
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

cis-1-(Boc-amino)-3-(hydroxymethyl)cyclobutane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL CIS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE

There total 7 articles about TERT-BUTYL CIS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate (142733-63-9,1101173-77-6) → cis-3-hydroxymethyl-1-<(t-butoxycarbonyl)amino>cyclobutane (142733-64-0,167081-37-0)

Guidance literature:

With sodium tetrahydroborate; calcium chloride; In ethanol; for 12h; Ambient temperature;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + tert-butyl N-(3-iodocyclobutyl)carbamate (1389264-12-3,1389264-19-0,1824239-57-7) → tert-butyl(3-(hydroxymethyl)cyclobutyl) carbamate (130369-05-0,167081-37-0) + cis-3-hydroxymethyl-1-<(t-butoxycarbonyl)amino>cyclobutane (142733-64-0,167081-37-0)

Guidance literature:

With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at 20 ℃; for 16h; Overall yield = 83 percent; Irradiation;

DOI:10.1039/d1sc03083c

Reference yield:

methyl 3-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate (1101173-77-6) → cis-3-hydroxymethyl-1-<(t-butoxycarbonyl)amino>cyclobutane (142733-64-0,167081-37-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

upstream raw materials:

cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate

methyl 3-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate

3-oxocyclobutanecarboxylic acid

methyl 3-oxocyclobutanecarboxylate

Downstream raw materials:

cis-(3-aminocyclobutyl)methanol hydrochloride

tert-butyl ((cis)-3-(aminomethyl)cyclobutyl)carbamate

tert-butyl N-(cis-3-formylcyclobutyl)carbamate

cis-3-amino-1-cyclobutanemethanol

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