METHYL 1H-PYRROLO[2,3-C]PYRIDINE-5-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1H-PYRROLO[2,3-C]PYRIDINE-5-CARBOXYLATE
• CAS No.: 147071-00-9
• Molecular Formula: C9H8 N2 O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 147071-00-9.mol

Synonyms:Methyl1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Chemical Property of METHYL 1H-PYRROLO[2,3-C]PYRIDINE-5-CARBOXYLATE

Chemical Property:

• Boiling Point: 383.1±22.0 °C(Predicted)
• PKA: 13.75±0.40(Predicted)
• PSA: 54.98000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 1.34950

Purity/Quality:

97% ^*data from raw suppliers

methyl1H-pyrrolo[2,3-c]pyridine-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1H-PYRROLO[2,3-C]PYRIDINE-5-CARBOXYLATE

There total 1 articles about METHYL 1H-PYRROLO[2,3-C]PYRIDINE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 4-[(1E)-2-(dimethylamino)ethenyl]-5-nitro-2-pyridinecarboxylate (868551-31-9) → methyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate (147071-00-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 25 - 50 ℃; for 40.666h; under 1551.49 - 2585.81 Torr;

Reference yield: 100.0%

methyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate (147071-00-9) + m-(bromomethyl)benzonitrile (28188-41-2) → methyl 1-(3-cyanobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (1195973-29-5)

Guidance literature:

methyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 10 ℃; for 2.25h; Inert atmosphere;

m-(bromomethyl)benzonitrile; In tetrahydrofuran; mineral oil; at 10 - 20 ℃;

DOI:10.1021/jm900862n

Reference yield: 88.0%

methyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate (147071-00-9) + 4-Fluorobenzyl bromide (459-46-1) → methyl 1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (868551-32-0)

Guidance literature:

methyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 10 ℃; for 2.25h; Inert atmosphere;

4-Fluorobenzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 10 - 20 ℃;

DOI:10.1021/jm900862n

upstream raw materials:

methyl 4-[(1E)-2-(dimethylamino)ethenyl]-5-nitro-2-pyridinecarboxylate

Downstream raw materials:

methyl 1-(2,4-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

methyl 1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

methyl 1-(4-cyanobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

methyl 1-(3-cyanobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 147071-00-9 METHYL 1H-PYRROLO[2,3-C]PYRIDINE-5-CARBOXYLATE

Send

Send

Metric Ton KG G Pound L ML

Send

Send