Carbamic acid, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(phenylmethoxy)-1-(phenylmethyl)-3-pyrrolidinyl-, 1,1-dimethylethyl ester, 3S-3.alpha.,4.beta.,5.alpha.(R*)-

Base Information

Chemical Name:Carbamic acid, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(phenylmethoxy)-1-(phenylmethyl)-3-pyrrolidinyl-, 1,1-dimethylethyl ester, 3S-3.alpha.,4.beta.,5.alpha.(R*)-
CAS No.:149625-46-7
Molecular Formula:C₂₈H₃₈N₂O₅
Molecular Weight:482.62
Hs Code.:
Mol file:149625-46-7.mol

Carbamic acid, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(phenylmethoxy)-1-(phenylmethyl)-3-pyrrolidinyl-, 1,1-dimethylethyl ester, 3S-3.alpha.,4.beta.,5.alpha.(R*)-

Synonyms:Carbamic acid, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(phenylmethoxy)-1-(phenylmethyl)-3-pyrrolidinyl-, 1,1-dimethylethyl ester, 3S-3.alpha.,4.beta.,5.alpha.(R*)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(phenylmethoxy)-1-(phenylmethyl)-3-pyrrolidinyl-, 1,1-dimethylethyl ester, 3S-3.alpha.,4.beta.,5.alpha.(R*)-

Chemical Property:

Boiling Point:574.4±50.0 °C(Predicted)
PKA:11.45±0.60(Predicted)
PSA：69.26000
Density:1.17±0.1 g/cm3(Predicted)
LogP:4.82980

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(phenylmethoxy)-1-(phenylmethyl)-3-pyrrolidinyl-, 1,1-dimethylethyl ester, 3S-3.alpha.,4.beta.,5.alpha.(R*)-

There total 11 articles about Carbamic acid, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(phenylmethoxy)-1-(phenylmethyl)-3-pyrrolidinyl-, 1,1-dimethylethyl ester, 3S-3.alpha.,4.beta.,5.alpha.(R*)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 149625-45-6
3-O-benzyl-2-t-butyloxycarbonylamino-2-deoxy-5,6-O-isopropylidene-1,4-di-O-methanesulfonyl-D-glucitol

: 100-46-9
benzylamine

: 149625-46-7
3-O-benzyl-1,4-(N-benzylimino)-2-t-butyloxycarbonylamino-1,2,4-trideoxy-5,6-O-isopropylidene-D-glucitol

Guidance literature:: at 70 ℃;
DOI:10.1016/S0040-4039(00)79188-X DOI:10.1016/S0040-4020(01)89338-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 149625-46-7
3-O-benzyl-1,4-(N-benzylimino)-2-t-butyloxycarbonylamino-1,2,4-trideoxy-5,6-O-isopropylidene-D-glucitol

Guidance literature:: Multi-step reaction with 3 steps

1: KHCO₃ / dioxane; H₂O / Ambient temperature

2: 82 percent / pyridine

3: 66 percent / 70 °C

With potassium hydrogencarbonate; In 1,4-dioxane; pyridine; water;
DOI:10.1016/S0040-4020(01)89338-8

Reference yield:

: 117177-19-2
2-methyl-(1,2-dideoxy-5,6-O-isopropylidene-α-D-glucofurano)-<2,1-d>-2-oxazoline

: 149625-46-7
3-O-benzyl-1,4-(N-benzylimino)-2-t-butyloxycarbonylamino-1,2,4-trideoxy-5,6-O-isopropylidene-D-glucitol

Guidance literature:: Multi-step reaction with 8 steps

1: 80percent oily NaH / dimethylformamide / Ambient temperature

2: 10percent aq. HOAc / methanol / 7 h / Ambient temperature

3: NaBH₄ / methanol / 1 h / Ambient temperature

4: pyridine / Ambient temperature

5: 1M aq. NaOH / methanol / 7 h / Heating

6: KHCO₃ / dioxane; H₂O / Ambient temperature

7: 82 percent / pyridine

8: 66 percent / 70 °C

With sodium hydroxide; sodium tetrahydroborate; sodium hydride; potassium hydrogencarbonate; acetic acid; In 1,4-dioxane; pyridine; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89338-8