(E)-5-(2-Bromovinyl)-6-aza-2'-deoxyuridine

Base Information

Chemical Name:(E)-5-(2-Bromovinyl)-6-aza-2'-deoxyuridine
CAS No.:97776-64-2
Molecular Formula:C₁₀H₁₂BrN₃O₅
Molecular Weight:334.126
Hs Code.:

Synonyms:(E)-5-(2-Bromovinyl)-6-aza-2'-deoxyuridine;97776-64-2;6-[(E)-2-bromovinyl]-2-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazine-3,5-dione

Suppliers and Price of (E)-5-(2-Bromovinyl)-6-aza-2'-deoxyuridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (E)-5-(2-Bromovinyl)-6-aza-2'-deoxyuridine

Chemical Property:

Density:2.02g/cm³
XLogP3:-0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:332.99603
Heavy Atom Count:19
Complexity:452

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C(=O)NC(=O)C(=N2)C=CBr)CO)O
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C(=O)NC(=O)C(=N2)/C=C/Br)CO)O

Technology Process of (E)-5-(2-Bromovinyl)-6-aza-2'-deoxyuridine

There total 8 articles about (E)-5-(2-Bromovinyl)-6-aza-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 97776-68-6
(E)-5-(2-carboxyvinyl)-6-aza-2'-deoxyuridine

: 97776-64-2
6-((E)-2-Bromo-vinyl)-2-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: With N-Bromosuccinimide; potassium acetate; In water; at 60 ℃; for 1h;
DOI:10.1021/jm00155a035

Reference yield: 33.0%

: 97776-62-0,97776-63-1
(E)-5-(2-bromovinyl)-1-(2'-deoxy-3'-5'-di-O-p-toluoyl-D-erythro-pentafuranosyl)-6-azauracil

: 97776-65-3
6-((E)-2-Bromo-vinyl)-2-((2S,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H-[1,2,4]triazine-3,5-dione

: 97776-64-2
6-((E)-2-Bromo-vinyl)-2-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: With sodium methylate; In methanol; for 2h; Ambient temperature;
DOI:10.1021/jm00155a035

Reference yield:

: 3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3
Hoffer's chlorosugar

: 97776-64-2
6-((E)-2-Bromo-vinyl)-2-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) hexamethyldisilazane (HMDS), chlorotrimethylsilane, 2.) stannic chloride / 1.) acetonitrile, reflux, 1 h, 2.) 1,2-dichloroethane, RT, 2.5 h

2: 33 percent / sodium methoxide / methanol / 2 h / Ambient temperature

With chloro-trimethyl-silane; sodium methylate; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol;
DOI:10.1021/jm00155a035