(E)-5-(2-Carboxyvinyl)-6-aza-2'-deoxyuridine

Base Information

Chemical Name:(E)-5-(2-Carboxyvinyl)-6-aza-2'-deoxyuridine
CAS No.:97776-68-6
Molecular Formula:C₁₁H₁₃N₃O₇
Molecular Weight:299.24
Hs Code.:

Synonyms:(E)-5-(2-Carboxyvinyl)-6-aza-2'-deoxyuridine;97776-68-6;(E)-3-[2-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,5-dioxo-1,2,4-triazin-6-yl]prop-2-enoic acid

Suppliers and Price of (E)-5-(2-Carboxyvinyl)-6-aza-2'-deoxyuridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (E)-5-(2-Carboxyvinyl)-6-aza-2'-deoxyuridine

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.83g/cm³
XLogP3:-1.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:299.07534976
Heavy Atom Count:21
Complexity:530

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C(=O)NC(=O)C(=N2)C=CC(=O)O)CO)O
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C(=O)NC(=O)C(=N2)/C=C/C(=O)O)CO)O

Technology Process of (E)-5-(2-Carboxyvinyl)-6-aza-2'-deoxyuridine

There total 3 articles about (E)-5-(2-Carboxyvinyl)-6-aza-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 97776-67-5
(E)-5-(2-carbomethoxyvinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentafuranosyl)-6-azauracil

: 97776-68-6
(E)-5-(2-carboxyvinyl)-6-aza-2'-deoxyuridine

Guidance literature:: With potassium hydroxide; water; In methanol; for 1h; Heating;
DOI:10.1021/jm00155a035

Reference yield:

: 20258-32-6
5-hydroxymethyl-(3,5-di-O-p-toluoyl)-6-aza-2-deoxyuridine

: 97776-68-6
(E)-5-(2-carboxyvinyl)-6-aza-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / diphenyl diselenide, 70percent aq. tert-butyl hydroperoxide / benzene / 4.5 h / Heating

2: 85 percent / acetonitrile / 5 h / Heating

3: 82 percent / KOH, H₂O / methanol / 1 h / Heating

With tert.-butylhydroperoxide; potassium hydroxide; diphenyl diselenide; water; In methanol; acetonitrile; benzene;
DOI:10.1021/jm00155a035

Reference yield:

: 97776-66-4
5-formyl-1-(2'-deoxy-3'-5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6-azauracil

: 97776-68-6
(E)-5-(2-carboxyvinyl)-6-aza-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / acetonitrile / 5 h / Heating

2: 82 percent / KOH, H₂O / methanol / 1 h / Heating

With potassium hydroxide; water; In methanol; acetonitrile;
DOI:10.1021/jm00155a035