2(3H)-Furanone,3-acetyl-5-ethoxydihydro-3,4-dimethyl-,(3alpha,4alpha,5bta)-(9CI)

Base Information

• Chemical Name: 2(3H)-Furanone,3-acetyl-5-ethoxydihydro-3,4-dimethyl-,(3alpha,4alpha,5bta)-(9CI)
• CAS No.: 148840-16-8
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.235
• Mol file: 148840-16-8.mol

Synonyms:2(3H)-Furanone,3-acetyl-5-ethoxydihydro-3,4-dimethyl-,(3alpha,4alpha,5bta)-(9CI)

Chemical Property of 2(3H)-Furanone,3-acetyl-5-ethoxydihydro-3,4-dimethyl-,(3alpha,4alpha,5bta)-(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(3H)-Furanone,3-acetyl-5-ethoxydihydro-3,4-dimethyl-,(3alpha,4alpha,5bta)-(9CI)

There total 3 articles about 2(3H)-Furanone,3-acetyl-5-ethoxydihydro-3,4-dimethyl-,(3alpha,4alpha,5bta)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Acetyl-5-ethoxy-4-methyltetrahydrofuran-2-one + methyl iodide (74-88-4) → dihydro-3α-acetyl-5β-ethoxy-3β,4β-dimethyl-2(3H)-furanone (148840-17-9,148840-16-8) + dihydro-3α-acetyl-5β-ethoxy-3α,4β-dimethyl-2(3H)-furanone (148840-17-9)

Guidance literature:

With potassium carbonate; In acetone; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00121a025

Reference yield:

1,1-dimethylethyl 2α-ethoxy-3α-methyl-1α-(1-((1,1-dimethylethyl)dimethylsilyloxy)vinyl)-cyclopropane-1β-carboxylate → dihydro-3α-acetyl-5β-ethoxy-3β,4β-dimethyl-2(3H)-furanone (148840-17-9,148840-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / TFA / CH₂Cl₂ / a) -78 deg C, 30 min, b) from -78 deg C to RT, 30 min

2: 1.) TlOEt / 1.) ligroin, toluene, 30 min, 2.)reflux, 50 min

With thallium (I) ethoxide; trifluoroacetic acid; In dichloromethane;

Reference yield:

dihydro-3α-acetyl-5β-ethoxy-4β-methyl-2(3H)-furanone + methyl iodide (74-88-4) → dihydro-3α-acetyl-5β-ethoxy-3β,4β-dimethyl-2(3H)-furanone (148840-17-9,148840-16-8) + dihydro-3α-acetyl-5β-ethoxy-3α,4β-dimethyl-2(3H)-furanone (148840-17-9)

Guidance literature:

With thallium (I) ethoxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) ligroin, toluene, 30 min, 2.)reflux, 50 min;

upstream raw materials:

methyl iodide