4-Pyridinemethanamine,2-methoxy-(9CI)

Base Information

• Chemical Name: 4-Pyridinemethanamine,2-methoxy-(9CI)
• CAS No.: 148900-69-0
• Molecular Formula: C7H10 N2 O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• Mol file: 148900-69-0.mol

Synonyms:(2-Methoxypyridin-4-ylmethyl)amine;1-(2-Methoxypyridin-4-yl)methanamine; 2-Methoxy-4-aminomethylpyridine;4-(Aminomethyl)-2-methoxypyridine; [(2-Methoxy-4-pyridyl)methyl]amine

Chemical Property of 4-Pyridinemethanamine,2-methoxy-(9CI)

Chemical Property:

• Vapor Pressure: 0.038mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 240.6°Cat760mmHg
• PKA: 7.41±0.29(Predicted)
• Flash Point: 99.3°C
• PSA: 48.14000
• Density: 1.09g/cm³
• LogP: 1.24920
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Methoxypyridin-4-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2-Methoxypyridin-4-yl)methanamine is used as a preparation of tricyclic AKR1C3 dependent KARS inhibitors.

Technology Process of 4-Pyridinemethanamine,2-methoxy-(9CI)

There total 3 articles about 4-Pyridinemethanamine,2-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyano-2-methoxypyridine (72716-86-0) → (2-methoxy-pyridin-4-yl)-methylamine (148900-69-0)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol; for 1.25h; under 3800 Torr;

DOI:10.1021/jm00068a014

Reference yield:

2-methoxypyridine-4-carboxamide → (2-methoxy-pyridin-4-yl)-methylamine (148900-69-0)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

2-methoxyisonicotinylcarboxamide → (2-methoxy-pyridin-4-yl)-methylamine (148900-69-0)

Guidance literature:

In tetrahydrofuran; methanol;

upstream raw materials:

4-cyano-2-methoxypyridine

Downstream raw materials:

4-(aminomethyl)pyridin-2(1H)-one hydrochloride

2-(4-chloro-phenoxy)-ethanesulfonic acid (2-methoxy-pyridin-4-ylmethyl)-amide

6-(2,3-dimethylphenyl)-4-N-[(2-methoxypyridin-4-yl)methyl]pyrimidine-2,4-diamine

4-(aminomethyl)-2(1H)-pyridinone

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY". Page/Page column 97-98. . Retrieved 2012/01/15.
• 2、 -. "SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE". . . Retrieved 2008/06/13.