2-Oxetanecarboxylicacid,4-oxo-,ethylester(9CI)

Base Information

• Chemical Name: 2-Oxetanecarboxylicacid,4-oxo-,ethylester(9CI)
• CAS No.: 150196-71-7
• Molecular Formula: C₆H₈O₄
• Molecular Weight: 144.127
• Mol file: 150196-71-7.mol

Synonyms:2-Oxetanecarboxylicacid, 4-oxo-, ethyl ester, (?à)-

Chemical Property of 2-Oxetanecarboxylicacid,4-oxo-,ethylester(9CI)

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

4-Oxo-2-oxetanecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Oxo-2-oxetanecarboxylic Acid Ethyl Ester is the ethyl ester derivative of 4-Oxo-2-oxetanecarboxylic Acid (O858455); a building block in copolymers which are used as coating materials for medical devices.

Technology Process of 2-Oxetanecarboxylicacid,4-oxo-,ethylester(9CI)

There total 6 articles about 2-Oxetanecarboxylicacid,4-oxo-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + trimetylsilylketene (4071-85-6) → (2R)-4-oxo-oxetane-2-carboxylic acid ethyl ester (107285-64-3,150196-71-7)

Guidance literature:

glyoxylic acid ethyl ester; trimetylsilylketene; With Quinine; Rh₂[(4S)-4-methoxycarbonyl-1-azetin-2-olato-O,N]4; In dichloromethane; at 20 ℃; for 20h;

With potassium fluoride; In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1002/adsc.200404245

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + trimetylsilylketene (4071-85-6) → 4-oxo-oxetane-2-carboxylic acid ethyl ester (107285-64-3,150196-71-7)

Guidance literature:

glyoxylic acid ethyl ester; trimetylsilylketene; Rh₂(S,S-MenthAZ)4; In dichloromethane; at 20 ℃; for 20h;

With potassium fluoride; In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1002/adsc.200404245

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + trimetylsilylketene (4071-85-6) → (2S)-4-oxo-oxetane-2-carboxylic acid ethyl ester (353302-29-1,107285-64-3,150196-71-7) + (2R)-4-oxo-oxetane-2-carboxylic acid ethyl ester (107285-64-3,150196-71-7)

Guidance literature:

[Cu((S,S)-((CH₃)3CCHCH₂OCN)2C(CH₃)2)](SbF₆)2; In dichloromethane; at -78 ℃; for 0.166667h; Further Variations:; Catalysts; Solvents; Temperatures; reaction time; Product distribution;

DOI:10.1021/ol016096z

upstream raw materials:

glyoxylic acid ethyl ester

trimetylsilylketene

Refernces

• 1、 Evans, David A.,Janey, Jacob M.. "C2-Symmetric Cu(II) Complexes as Chiral Lewis Acids. Catalytic, Enantioselective Cycloadditions of Silyl Ketenes". . p. 2125 - 2128. Retrieved 2007/10/03.