TERT-BUTYL 4-(3-AMINOPROPYL)PIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(3-AMINOPROPYL)PIPERIDINE-1-CARBOXYLATE
• CAS No.: 150349-65-8
• Molecular Formula: C13H26 N2 O2
• Molecular Weight: 242.362
• Hs Code.: 2933399090
• Mol file: 150349-65-8.mol

Synonyms:1-tert-Butoxycarbonyl-4-piperidinepropanamine;4-(3-Aminopropyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl4-(3-aminopropyl)piperidine-1-carboxylate

Chemical Property of TERT-BUTYL 4-(3-AMINOPROPYL)PIPERIDINE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.000149mmHg at 25°C
• Refractive Index: 1.48
• Boiling Point: 332.1°C at 760 mmHg
• PKA: 10.55±0.10(Predicted)
• Flash Point: 154.7°C
• PSA: 55.56000
• Density: 0.999g/cm³
• LogP: 3.01060

Purity/Quality:

98%min ^*data from raw suppliers

1-Boc-4-(3-aminopropyl)piperidine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(3-AMINOPROPYL)PIPERIDINE-1-CARBOXYLATE

There total 7 articles about TERT-BUTYL 4-(3-AMINOPROPYL)PIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(3-azido-propyl)-piperidine-1-carboxylic acid tert-butyl ester (946517-74-4) → 4-(3-amino-propyl)-piperidine-1-carboxylic acid tert-butyl ester (150349-65-8)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

Reference yield: 87.0%

tert-butyl 4-(3-(1,3-dioxoisoindolin-2-yl)propyl)piperidine-1-carboxylate → 4-(3-amino-propyl)-piperidine-1-carboxylic acid tert-butyl ester (150349-65-8)

Guidance literature:

With ethanol; hydrazine hydrate; for 3h; Reflux;

DOI:10.1016/j.bioorg.2021.105411

Reference yield:

tert-butyl 4-(2-cyanoethyl)piperidine-1-carboxylate (161975-20-8) → 4-(3-amino-propyl)-piperidine-1-carboxylic acid tert-butyl ester (150349-65-8)

Guidance literature:

With H₂; PtO₂; In ethanol; dichloromethane;

upstream raw materials:

tert-butyl 4-(2-cyanoethyl)piperidine-1-carboxylate

4-(3-azido-propyl)-piperidine-1-carboxylic acid tert-butyl ester

3-(piperidin-4-yl)propan-1-ol

N-Boc-piperidin-4-yl-propanol

Downstream raw materials:

4-[2-(4-bromo-2-chlorophenoxy)phenylsulfamoyl]-N-(3-piperidin-4-ylpropyl)benzamide hydrochloride

Refernces

• 1、 -. "N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE". Page/Page column 73; 74. . Retrieved 2018/04/27.
• 2、 -. "NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS". Page/Page column 29. . Retrieved 2008/12/05.