6H-Pyrido[1,2-a]pyrazin-6-one,octahydro-(9CI)

Base Information

• Chemical Name: 6H-Pyrido[1,2-a]pyrazin-6-one,octahydro-(9CI)
• CAS No.: 151665-85-9
• Molecular Formula: C8H14 N2 O
• Molecular Weight: 154.212
• Mol file: 151665-85-9.mol

Synonyms:6H-Pyrido[1,2-a]pyrazin-6-one,octahydro-, (?à)-

Chemical Property of 6H-Pyrido[1,2-a]pyrazin-6-one,octahydro-(9CI)

Chemical Property:

• PSA: 32.34000
• LogP: 0.23740

Purity/Quality:

98% ^*data from raw suppliers

Octahydro-pyrido[1,2-a]pyrazin-6-one 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6H-Pyrido[1,2-a]pyrazin-6-one,octahydro-(9CI)

There total 2 articles about 6H-Pyrido[1,2-a]pyrazin-6-one,octahydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-pyrazin-2-yl-butyric acid ethyl ester (671212-30-9) → octahydro-6H-pyrido[1,2-a]pyrazin-6-one (151665-85-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 60h; under 3102.89 Torr;

DOI:10.1016/j.bmc.2003.10.025

Reference yield:

2-Methylpyrazine (109-08-0) → octahydro-6H-pyrido[1,2-a]pyrazin-6-one (151665-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 15 percent / tetrahydrofuran; hexane / 1 h / -78 °C

2.1: 60 percent / H₂ / Pd/C / ethanol / 60 h / 3102.89 Torr

With n-butyllithium; hydrogen; diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;

DOI:10.1016/j.bmc.2003.10.025

Reference yield: 44.0%

2-fluorobenzenesulfonyl chloride (2905-21-7) + octahydro-6H-pyrido[1,2-a]pyrazin-6-one (151665-85-9) → 2-(2-Fluoro-benzenesulfonyl)-octahydro-pyrido[1,2-a]pyrazin-6-one (1182733-30-7)

Guidance literature:

With triethylamine; In DCM; acetonitrile; at 0 - 20 ℃;

upstream raw materials:

4-pyrazin-2-yl-butyric acid ethyl ester

2-Methylpyrazine

Downstream raw materials:

2-(2-Fluoro-benzenesulfonyl)-octahydro-pyrido[1,2-a]pyrazin-6-one

Refernces

• 1、 Scapecchi, Serena,Martini, Elisabetta,Manetti, Dina,Ghelardini, Carla,Martelli, Cecilia,Dei, Silvia,Galeotti, Nicoletta,Guandalini, Luca,Romanelli, Maria Novella,Teodori, Elisabetta. "Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs". . p. 71 - 85. Retrieved 2007/10/03.