TETRAETHYL(CARBOXYETHYLIDENE)BISPHOSPHONATE

Base Information

• Chemical Name: TETRAETHYL(CARBOXYETHYLIDENE)BISPHOSPHONATE
• CAS No.: 151869-73-7
• Molecular Formula: C₁₁H₂₄O₈P₂
• Molecular Weight: 346.254
• Mol file: 151869-73-7.mol

Synonyms:3,3-Bis(diethylphosphono)propanoicacid;Tetraethyl 2-Carboxyethylene-1,1-bisphosphonate;

Chemical Property of TETRAETHYL(CARBOXYETHYLIDENE)BISPHOSPHONATE

Chemical Property:

• Boiling Point: 463 °C at 760 mmHg
• PKA: 3.71±0.10(Predicted)
• Flash Point: 233.8 °C
• PSA: 127.98000
• Density: 1.241 g/cm³
• LogP: 3.31940

Purity/Quality:

99% ^*data from raw suppliers

3,3-Bis(diethoxyphosphoryl)propanoic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TETRAETHYL(CARBOXYETHYLIDENE)BISPHOSPHONATE

There total 4 articles about TETRAETHYL(CARBOXYETHYLIDENE)BISPHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 3,3-bis(diethoxyphosphinyl)propanoate (1112-29-4) → 3,3-bis(diethylphosphono)propanoic acid (151869-73-7)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In ethanol; water;

Reference yield: 75.0%

tetraethyl 2-tert-butoxycarbonylethylene-1,1-bisphosphonate (446061-28-5) → 3,3-bis(diethylphosphono)propanoic acid (151869-73-7)

Guidance literature:

With trifluoroacetic acid; for 0.0416667h; Inert atmosphere;

DOI:10.1021/jm801007z

Reference yield: 72.0%

→ 3,3-bis(diethylphosphono)propanoic acid (151869-73-7)

Guidance literature:

upstream raw materials:

ethyl 3,3-bis(diethoxyphosphinyl)propanoate

Tetraethyl methylenediphosphonate

tetraethyl 2-tert-butoxycarbonylethylene-1,1-bisphosphonate