1112-29-4

Basic information

• Product Name: Tetraethyl(ethoxycarbonylethylidene)bisphosphonate
• Synonyms: Tetraethyl(ethoxycarbonylethylidene)bisphosphonate;Ethyl 3,3-bis(diethoxyphosphoryl)propanoate
• CAS NO: 1112-29-4
• Molecular Formula: C13H28O8P2
• Molecular Weight: 374.31
• Mol File: 1112-29-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tetraethyl(ethoxycarbonylethylidene)bisphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Tetraethyl(ethoxycarbonylethylidene)bisphosphonate(1112-29-4)
• EPA Substance Registry System: Tetraethyl(ethoxycarbonylethylidene)bisphosphonate(1112-29-4)

Safety Data

• Hazardous Substances Data: 1112-29-4(Hazardous Substances Data)

Usage

Description

Tetraethyl(ethoxycarbonylethylidene)bisphosphonate, a bisphosphonate derivative with the molecular formula C10H24O10P2, is a chemical compound that has garnered attention in the pharmaceutical industry. It is recognized for its potential to treat bone diseases such as osteoporosis and Paget's disease. Tetraethyl(ethoxycarbonylethylidene)bisphosphonate's ability to inhibit bone resorption and promote bone mineralization positions it as a promising candidate for developing new therapies for bone-related disorders.

Uses

Used in Pharmaceutical Industry:
Tetraethyl(ethoxycarbonylethylidene)bisphosphonate is used as a potential treatment for bone diseases for its capacity to inhibit bone resorption and promote bone mineralization. This makes it a valuable asset in the development of new therapies aimed at strengthening and protecting bones, particularly for conditions like osteoporosis and Paget's disease.
Used in Bone Health Management:
In the realm of bone health, Tetraethyl(ethoxycarbonylethylidene)bisphosphonate is utilized to prevent bone loss, a critical factor in maintaining the structural integrity and functionality of the skeletal system. Its role in bone mineralization further underscores its importance in the management and treatment of bone disorders.
Used in Research and Development:
Tetraethyl(ethoxycarbonylethylidene)bisphosphonate is also used as a subject of research for understanding its mechanisms of action and potential side effects. This research is vital for refining its application and optimizing its use in clinical settings, ensuring the safety and efficacy of treatments that incorporate this compound.

Upstream product

• 40149-32-4 ethyl 3-chloro-2-hydroxypropanoate 
• 122-52-1 triethyl phosphite 
• 762-04-9 Diethyl phosphonate 
• 623-47-2 propynoic acid ethyl ester 
• 23332-36-7 P,P'-methanediyl-bis-phosphonic acid tetraethyl ester; sodium salt 
• 105-39-5 chloroacetic acid ethyl ester 
• 1660-94-2 Tetraethyl methylenediphosphonate 
• 762-04-9 phosphonic acid diethyl ester 
• 105-36-2 ethyl bromoacetate 
• 78626-48-9 ethyl α-acetoxy-β-chlorolactate 

Downstream Products

• 151869-73-7 3,3-bis(diethylphosphono)propanoic acid 

Relevant articles and documents

Role of base catalysts upon the Pudovik reaction: Unexpected synthesis of 1,2-dihydropyridine phosphonate derivatives

The role of base catalysts (CsNaX zeolite, hydrotalcite, triethylamine and pyridine derivatives) upon the regioselectivity of the Pudovik reaction is studied. The unexpected synthesis of stable 1,2-dihydropyridine phosphonate derivatives via a one-pot addition reaction under mild conditions is described.

Dual Radical/Polar Pudovik Reaction: Application Field of New Activation Methods

The Pudovik reaction (addition of organophosphorus compounds containing a labile P-H bond with alkenes and alkynes) can progess via a radical or (and) ionic mechanism. A comparative and systematic study including various reagents and different activation methods (heating, photochemical or ultrasonic irradiation, and dry medium supported reactions) is presented. Photolysis is the most efficient method for the radical processes, but in a few examples, ultrasonic irradiation can be more appropriate since the reaction time is shorter and ultrasound did not induce side-reactions (in particular Z/E isomerization). Dry medium process on basic solid support is the best anionic activation (yield, time, selectivity, purification facilities). Ultrasound, by its mechanical effects, can contribute to increase yield compared to the classical thermal method under these basic conditions. All the activation methods are efficient whatever the unsaturated substrates for the phosphine reactivity, whereas the appropriate activation method is exclusively determined by the nature of the unsaturated system for the thiophosphine (or phosphine oxide) reactivity.

SYNTHESE DE CONJUGUES GEM-BISPHOSPHONIQUES DE DERIVES DE LA CORTISONE

Some gem-bisphosphonic cortico-steroid conjugates are prepared by esterification between gem-bisphosphonate carboxylic acids and steroid primary alcohols.These original products take place in a biological study about a delivery-targeting concept of active constituents in bone therapy, with the assistance of gem-bisphosphonic building-blocks. Key words: gem-bisphosphonate; gem-bisphosphonic; tetraethyl ethylidene gem-bisphosphonate; corticosteroids; esterification; anti-inflammatory; delivery-targeting concept.