(2-NAPHTHYL)METHYLZINC BROMIDE

Base Information

• Chemical Name: (2-NAPHTHYL)METHYLZINC BROMIDE
• CAS No.: 152329-44-7
• Molecular Formula: C₁₁H₉BrZn
• Molecular Weight: 286.486
• Mol file: 152329-44-7.mol

Synonyms:(2-NAPHTHYL)METHYLZINC BROMIDE;(2-NAPHTHYLMETHYL)ZINC BROMIDE, 0.5M SOL UTION IN TETRAHYDROFURAN;(2-naphthylmethyl)zinc bromide solution

Chemical Property of (2-NAPHTHYL)METHYLZINC BROMIDE

Chemical Property:

• Refractive Index: ">
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: g/cm³
• LogP: 3.99860
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2-Naphthylmethyl)zinc bromide solution 0.5M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 14-19-22-36/38-40-36/37-11
• Safety Statements: 16-26-33-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2-Naphthylmethyl)zinc bromide can be used as a reagent for the synthesis of: 4-(5,6-dimethoxy-2-(naphthalen-2-ylmethyl)pyridin-3-yl)benzonitrile from 4-(2-bromo-5,6-dimethoxypyridin-3-yl)benzonitrile using Pd catalyst. (E)-stilbene, (2,2′-[1,4-phenylenedi-(1E)-2,1-ethenediyl]bis[naphthalene]) from 1,4-benzenedicarboxaldehyde in the presence of Pd catalyst and a silylating agent.

Technology Process of (2-NAPHTHYL)METHYLZINC BROMIDE

There total 1 articles about (2-NAPHTHYL)METHYLZINC BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-bromomethylnaphthyl bromide (939-26-4) + zinc (7440-66-6) → (naphthalen-2-ylmethyl)zinc(II) bromide (152329-44-7)

Guidance literature:

zinc; With chloro-trimethyl-silane; ethylene dibromide; In tetrahydrofuran; at 50 ℃; for 0.0166667h; Inert atmosphere; Sealed tube;

2-bromomethylnaphthyl bromide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b00031

Reference yield: 72.0%

P-toluenesulfonyl cyanide (19158-51-1) + (naphthalen-2-ylmethyl)zinc(II) bromide (152329-44-7) → 2-methyl-1-naphthonitrile (20944-85-8)

Guidance literature:

In tetrahydrofuran; at 0 - 25 ℃;

DOI:10.1016/S0040-4039(00)60640-8

Reference yield:

7-bromo-N,3-ditrityl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine + (naphthalen-2-ylmethyl)zinc(II) bromide (152329-44-7) → C54H41N5

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; ethylene dibromide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115723

upstream raw materials:

2-bromomethylnaphthyl bromide

zinc

Downstream raw materials:

2-methyl-1-naphthonitrile

Refernces

• 1、 Smirnov, Vladimir O.,Struchkova, Marina I.,Arkhipov, Dmitry E.,Korlyukov, Alexander A.,Dilman, Alexander D.. "Synthesis of gem -difluorinated nitroso compounds". . p. 11819 - 11823. Retrieved 2015/01/16.