2-(2,6-Difluoro-phenyl)-benzothiazole

Base Information

• Chemical Name: 2-(2,6-Difluoro-phenyl)-benzothiazole
• CAS No.: 152993-87-8
• Molecular Formula: C13H7 F2 N S
• Molecular Weight: 247.268
• Mol file: 152993-87-8.mol

Synonyms:2-(2,6-Difluorophenyl)benzothiazole

Chemical Property of 2-(2,6-Difluoro-phenyl)-benzothiazole

Chemical Property:

• PSA: 41.13000
• LogP: 4.24150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,6-Difluoro-phenyl)-benzothiazole

There total 6 articles about 2-(2,6-Difluoro-phenyl)-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,6-difluorobenzaldehyde (437-81-0) + 2-amino-benzenethiol (137-07-5) → 2-(2,6-difluorophenyl)-1,3-benzothiazole (152993-87-8)

Guidance literature:

With Fe₃O₄(at)SiO₂ nanoparticles supported on tungstosilicic acid; In water; at 70 ℃; for 8h;

DOI:10.1007/s13738-013-0400-8

Reference yield: 72.0%

2-amino-benzenethiol (137-07-5) + 2,6-difluorobenzoic acid (385-00-2) → 2-(2,6-difluorophenyl)-1,3-benzothiazole (152993-87-8)

Guidance literature:

With methanesulfonic acid; silica gel; at 140 ℃; for 12h;

DOI:10.1080/00397910802431214

Reference yield: 69.0%

2-(2-fluorophenyl)-1,3-benzothiazole (1747-46-2) → 2-(2,6-difluorophenyl)-1,3-benzothiazole (152993-87-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-fluorobis(benzenesulfon)imide; L-proline; In cyclohexane; at 120 ℃; for 5h; regioselective reaction; Sealed tube;

DOI:10.1016/j.tet.2013.11.034

upstream raw materials:

2-amino-benzenethiol

2,6-difluorobenzoic acid

1,3-Benzothiazole

2-(2-fluorophenyl)-1,3-benzothiazole