(S)-(+)-P-TOLUENESULFINAMIDE N-BENZYLIDENE

Base Information

• Chemical Name: (S)-(+)-P-TOLUENESULFINAMIDE N-BENZYLIDENE
• CAS No.: 153277-49-7
• Molecular Formula: C14H13 N O S
• Molecular Weight: 243.329
• Mol file: 153277-49-7.mol

Synonyms:Benzenesulfinamide,4-methyl-N-(phenylmethylene)-, (S)-;(S)-N-(Benzylidene)-4-methylbenzenesulfinamide

Chemical Property of (S)-(+)-P-TOLUENESULFINAMIDE N-BENZYLIDENE

Chemical Property:

• PSA: 48.64000
• LogP: 4.00240

Purity/Quality:

98%min ^*data from raw suppliers

(S)-(+)-PARA-TOLUENESULFINAMIDE N-BENZYLIDENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(+)-P-TOLUENESULFINAMIDE N-BENZYLIDENE

There total 8 articles about (S)-(+)-P-TOLUENESULFINAMIDE N-BENZYLIDENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-tolylsulfinyl amide (6873-55-8) + benzaldehyde (100-52-7) → (S)-N-benzylidene-4-toluenesulfinamide (153277-49-7)

Guidance literature:

With pyrrolidine; In dichloromethane; at 60 ℃; for 1h; Molecular sieve;

DOI:10.1021/ja4111418

Reference yield: 98.0%

benzaldehyde (100-52-7) + (S)-p-toluenesulfinimide (188447-91-8) → (S)-N-benzylidene-4-toluenesulfinamide (153277-49-7)

Guidance literature:

With titanium(IV) tetraethanolate; at 70 ℃; for 1h; Neat (no solvent); Microwave irradiation; Inert atmosphere;

DOI:10.1021/jo300919x

Reference yield: 93.0%

(-)-menthyl (S)-p-toluenesulfinate + benzaldehyde (100-52-7) → (S)-N-benzylidene-4-toluenesulfinamide (153277-49-7)

Guidance literature:

(-)-menthyl (S)-p-toluenesulfinate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 5h; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00625

upstream raw materials:

(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate

benzaldehyde

(S)-p-toluenesulfinimide

p-tolylsulfinyl amide

Downstream raw materials:

[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

[1S,(S)S]-N-{1-phenyl-2[(S)-2-(p-toluensulfinyl)phenyl]ethyl}-p-toluenesulfinamide

[1S,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]propyl}-p-toluenesulfinamide

(S)-1,2-diphenylethyl amine