1-[2-(4-Chloro-phenyl)-indolizin-3-YL]-ethanone

Base Information

Chemical Name:1-[2-(4-Chloro-phenyl)-indolizin-3-YL]-ethanone
CAS No.:58963-35-2
Molecular Formula:C16H12ClNO
Molecular Weight:269.72558
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10482611
Nikkaji Number:J1.136.883B
Wikidata:Q82319113
Mol file:58963-35-2.mol

Synonyms:58963-35-2;1-[2-(4-CHLORO-PHENYL)-INDOLIZIN-3-YL]-ETHANONE;1-(2-(4-Chlorophenyl)indolizin-3-yl)ethanone;1-[2-(4-chlorophenyl)indolizin-3-yl]ethanone;1-[2-(4-chlorophenyl)indolizin-3-yl]ethan-1-one;AVVAFECDGAMDDO-UHFFFAOYSA-;DTXSID10482611;MFCD08692544;AKOS005254775;InChI=1/C16H12ClNO/c1-11(19)16-15(12-5-7-13(17)8-6-12)10-14-4-2-3-9-18(14)16/h2-10H,1H3

Suppliers and Price of 1-[2-(4-Chloro-phenyl)-indolizin-3-YL]-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-[2-(4-CHLORO-PHENYL)-INDOLIZIN-3-YL]-ETHANONE 95.00%
5MG
$ 503.13

Total 5 raw suppliers

Chemical Property of 1-[2-(4-Chloro-phenyl)-indolizin-3-YL]-ethanone

Chemical Property:

Melting Point:86 °C(Solv: isopropanol (67-63-0))
Refractive Index:1.622
PSA：21.48000
Density:1.22g/cm³
LogP:4.46230
XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:269.0607417
Heavy Atom Count:19
Complexity:338

Purity/Quality:

95% ^*data from raw suppliers

1-[2-(4-CHLORO-PHENYL)-INDOLIZIN-3-YL]-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=C(C=C2N1C=CC=C2)C3=CC=C(C=C3)Cl

Technology Process of 1-[2-(4-Chloro-phenyl)-indolizin-3-YL]-ethanone

There total 3 articles about 1-[2-(4-Chloro-phenyl)-indolizin-3-YL]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 2-[(E)-2-(4-Chloro-phenyl)-vinyl]-1-(2-oxo-propyl)-pyridinium; bromide

: 58963-35-2
1-[2-(4-chloro-phenyl)-indolizin-3-yl]-ethanone

Guidance literature:: With tetrakis-pyridinecobalt(II) dichromate; triethylamine; In toluene; at 80 - 90 ℃; for 6h;
DOI:10.1055/s-1999-3673

Reference yield:

: 24470-01-7,5343-70-4
(E)-2-(4-chlorostyryl)pyridine

: 58963-35-2
1-[2-(4-chloro-phenyl)-indolizin-3-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / CHCl₃ / 1.) r.t., overnight, 2.) 50 - 60 deg C, several hours

2: 37 percent / tetrakis(pyridine)cobalt(II) dichromate, Et₃N / toluene / 6 h / 80 - 90 °C

With tetrakis-pyridinecobalt(II) dichromate; triethylamine; In chloroform; toluene;
DOI:10.1055/s-1999-3673