2-[2-(4-Chlorophenyl)ethenyl]pyridine

Base Information

• Chemical Name: 2-[2-(4-Chlorophenyl)ethenyl]pyridine
• CAS No.: 24470-01-7
• Molecular Formula: C13H10ClN
• Molecular Weight: 215.682
• Hs Code.: 2933399090
• NSC Number: 351871,488
• DSSTox Substance ID: DTXSID201346857
• Nikkaji Number: J187.522A,J303.374K
• Wikidata: Q63409336
• Mol file: 24470-01-7.mol

Synonyms:2-[2-(4-chlorophenyl)ethenyl]pyridine;5343-70-4;24470-01-7;NSC488;2-(4-Chlorostyryl)pyridine;(e)-2-(4-chlorostyryl)pyridine;NSC-488;DTXSID201346857;NSC351871;NSC-351871;2-[(E)-2-(4-Chlorophenyl)vinyl]pyridine;2-[(1E)-2-(4-Chlorophenyl)ethenyl]pyridine;2-(2-(4-CHLOROPHENYL)-TRANS-VINYL)PYRIDINE;Q63409336

Chemical Property of 2-[2-(4-Chlorophenyl)ethenyl]pyridine

Chemical Property:

• Boiling Point: 337.7±11.0 °C(Predicted)
• PKA: 4.54±0.10(Predicted)
• PSA: 12.89000
• Density: 1.212±0.06 g/cm3(Predicted)
• LogP: 3.90540
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 215.0501770
• Heavy Atom Count: 15
• Complexity: 207

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C=CC2=CC=C(C=C2)Cl
• Isomeric SMILES: C1=CC=NC(=C1)/C=C/C2=CC=C(C=C2)Cl

Technology Process of 2-[2-(4-Chlorophenyl)ethenyl]pyridine

There total 10 articles about 2-[2-(4-Chlorophenyl)ethenyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(4-chloro-phenylethynyl)-pyridine (80221-12-1) → (E)-2-(4-chlorostyryl)pyridine (24470-01-7,5343-70-4)

Guidance literature:

With water; potassium ethyl xanthogenate; In N,N-dimethyl-formamide; at 130 ℃; for 12h; stereoselective reaction; Schlenk technique;

DOI:10.1039/C9CC00128J

Reference yield: 78.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + 4-Chlorophenylboronic acid (1679-18-1) → (E)-2-(4-chlorostyryl)pyridine (24470-01-7,5343-70-4)

Guidance literature:

With 1,10-Phenanthroline; palladium(II) trifluoroacetate; oxygen; silver(l) oxide; In N,N-dimethyl-formamide; at 80 ℃; for 24h; under 760.051 Torr; Green chemistry;

DOI:10.1055/s-0034-1379994

Reference yield: 40.0%

α-picoline (109-06-8) + 4-chlorobenzylamine (104-86-9) → (E)-2-(4-chlorostyryl)pyridine (24470-01-7,5343-70-4)

Guidance literature:

With hydrogenchloride; iodine; In water; dimethyl sulfoxide; at 120 ℃; for 12h; stereoselective reaction;

DOI:10.1021/acs.joc.7b00856

upstream raw materials:

α-picoline

4-chlorobenzaldehyde

2-vinylpyridine

4-Chlorophenylboronic acid

Downstream raw materials:

1-[2-(4-chloro-phenyl)-indolizin-3-yl]-ethanone

2-(4-chlorostyryl)pyridine N-oxide