2-Propenoyl chloride,3-(4-methylphenyl)-

Base Information

• Chemical Name: 2-Propenoyl chloride,3-(4-methylphenyl)-
• CAS No.: 15851-89-5
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.634
• Mol file: 15851-89-5.mol

Synonyms:Cinnamoylchloride, p-methyl- (8CI); 3-(p-Tolyl)acryloyl chloride; 4-Methylcinnamoylchloride; p-Methylcinnamoyl chloride

Chemical Property of 2-Propenoyl chloride,3-(4-methylphenyl)-

Chemical Property:

• PSA: 17.07000
• LogP: 2.77360

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoyl chloride,3-(4-methylphenyl)-

There total 10 articles about 2-Propenoyl chloride,3-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-p-methylcinnamic acid (1866-39-3,940-61-4) → (E)-p-methylcinnamoyl chloride (15851-89-5,13565-07-6)

Guidance literature:

With thionyl chloride; In cyclohexane; for 3h; Heating;

DOI:10.1016/0031-6865(94)90040-X

Reference yield: 97.0%

4-methylcinnamic acid (1866-39-3,940-61-4) → 4-methylcinnamoyl chloride (13565-07-6,15851-89-5)

Guidance literature:

With phosgene; In water; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2019.02.074

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 4-methylcinnamoyl chloride (13565-07-6,15851-89-5)

Guidance literature:

Multi-step reaction with 2 steps

2: oxalyl dichloride / dichloromethane / 4 h / 0 - 20 °C

With oxalyl dichloride; In dichloromethane; 1: |Knoevenagel Condensation;

DOI:10.1021/acs.orglett.5b00009

upstream raw materials:

4-methylcinnamic acid

4-methyl-benzaldehyde

trans-p-methylcinnamic acid

oxalyl dichloride

Downstream raw materials:

C₂₄H₂₉NO₄

1-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-(3-p-tolyl-acryloyl)-piperazine

1-(3-p-tolyl-acryloyl)-piperazine

6-[4-((E)-3-p-Tolyl-acryloyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one