4-Amino-2-methylpyrimidine-5-carbaldehyde

Base Information

• Chemical Name: 4-Amino-2-methylpyrimidine-5-carbaldehyde
• CAS No.: 73-68-7
• Molecular Formula: C6H7N3O
• Molecular Weight: 137.141
• Hs Code.: 2933599090
• European Community (EC) Number: 889-506-8
• UNII: JSP59V23ZD
• DSSTox Substance ID: DTXSID40512617
• Nikkaji Number: J134.949J
• Wikidata: Q72439555
• Mol file: 73-68-7.mol

Synonyms:4-AMINO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE;73-68-7;4-AMINO-5-FORMYL-2-METHYLPYRIMIDINE;5-Pyrimidinecarboxaldehyde, 4-amino-2-methyl-;JSP59V23ZD;5-Pyrimidinecarboxaldehyde, 4-amino-2-methyl- (6CI,7CI,8CI,9CI);4-amino-2-methylpyrimidine-5-carboxaldehyde;UNII-JSP59V23ZD;SCHEMBL8626075;DTXSID40512617;NOHYIPRJOCCNMG-UHFFFAOYSA-N;AMY16058;BCP29738;MFCD09864101;AKOS002676257;AB53802;AS-38387;4-amino-2-methylpyrimidin-5-carboxaldehyde;2-METHYL-4-AMINO-5-FORMYLPYRIMIDINE;4-amino-2-methyl-5-Pyrimidinecarboxaldehyde;CS-0282337;FT-0687518;EN300-77770;J-514338;6-Imino-2-methyl-1,6-dihydropyrimidine-5-carbaldehyde;F2113-0624;Z1198235085;4-Amino-5-formyl-2-methylpyrimidine

Chemical Property of 4-Amino-2-methylpyrimidine-5-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.64
• Boiling Point: 295.533oC at 760 mmHg
• Flash Point: 132.534oC
• PSA: 68.87000
• Density: 1.293g/cm3
• LogP: 0.76090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 137.058911855
• Heavy Atom Count: 10
• Complexity: 128

Purity/Quality:

97% ^*data from raw suppliers

4-amino-2-methylpyrimidine-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C(C(=N1)N)C=O

Technology Process of 4-Amino-2-methylpyrimidine-5-carbaldehyde

There total 2 articles about 4-Amino-2-methylpyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vitamin B1 (59-43-8) → 4-amino-2-methylpyrimidine-5-carbaldehyde (73-68-7) + (4-methylthiazol-5-yl)acetic acid (5255-33-4)

Guidance literature:

With potassium permanganate; sulfuric acid; sodium sulfate; In water; at 25 ℃; Concentration; Temperature; Kinetics; Thermodynamic data;

DOI:10.1002/kin.20991

Reference yield:

vitamin B1 (59-43-8) → 5-hydroxyethyl-4-methylthiazole (137-00-8,8042-97-5) + 4-amino-2-methylpyrimidine-5-carbaldehyde (73-68-7)

Guidance literature:

With manganese(II) sulfate; perchloric acid; sulfuric acid; cerium(IV) ammonium sulfate; ammonium iron (II) sulfate; In water; at 25 ℃; Temperature; Kinetics;

DOI:10.1007/s00706-013-1005-8

Reference yield: 89.0%

4-amino-2-methylpyrimidine-5-carbaldehyde (73-68-7) + 4-fluorobenzoyl hydrazide (456-06-4) → N’-((4-amino-2-methylpyrimidin-5-yl)methylene)-4-fluorobenzohydrazide

Guidance literature:

With acetic acid; In ethanol; for 3h;

DOI:10.1016/j.bmc.2017.08.038

upstream raw materials:

vitamin B₁

Downstream raw materials:

6-(2-Fluoro-phenyl)-2-methyl-pyrido[2,3-d]pyrimidin-7-ylamine

6-(2,6-dichlorophenyl)-2-methylpyrido<2,3-d>pyrimidin-7-amine

2-Methyl-6-(2,4,6-trimethyl-phenyl)-pyrido[2,3-d]pyrimidin-7-ylamine

6-(2,3-Dichloro-phenyl)-2-methyl-pyrido[2,3-d]pyrimidin-7-ylamine