Technology Process of AG035029
There total 12 articles about AG035029 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide; water;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium acetate; acetic anhydride / toluene / 3.5 h
1.2: 18 h / 80 °C
1.3: 4 h / 40 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 5.25 h / 40 - 90 °C
3.1: hydrogen; palladium(II) hydroxide / tert-butyl methyl ether / 12 h / 2430.66 Torr / Inert atmosphere
4.1: tert-butyl methyl ether / 760.05 Torr / Heating; Inert atmosphere
4.2: 36 h / 65 °C / Heating; Inert atmosphere
5.1: potassium hydroxide / tetrahydrofuran; water / 3 h
With
hydrogen; potassium acetate; palladium(II) hydroxide; acetic anhydride; caesium carbonate; potassium hydroxide;
In
tetrahydrofuran; tert-butyl methyl ether; water; N,N-dimethyl-formamide; toluene;
2.1: |Michael Addition;
DOI:10.1021/op0601621
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 5.25 h / 40 - 90 °C
2.1: hydrogen; palladium(II) hydroxide / tert-butyl methyl ether / 12 h / 2430.66 Torr / Inert atmosphere
3.1: tert-butyl methyl ether / 760.05 Torr / Heating; Inert atmosphere
3.2: 36 h / 65 °C / Heating; Inert atmosphere
4.1: potassium hydroxide / tetrahydrofuran; water / 3 h
With
hydrogen; palladium(II) hydroxide; caesium carbonate; potassium hydroxide;
In
tetrahydrofuran; tert-butyl methyl ether; water; N,N-dimethyl-formamide;
1.1: |Michael Addition;
DOI:10.1021/op0601621
