65361-82-2

Basic information

• Product Name: 3-(BENZYLOXY)-O-TOLUIDINE
• Synonyms: 3-(BENZYLOXY)-O-TOLUIDINE;3-(Benzyloxy)-o-toluidine HCl;BenzenaMine, 2-Methyl-3-(phenylMethoxy)-
• CAS NO: 65361-82-2
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.27
• Product Categories: pharmacetical
• Mol File: 65361-82-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 42-44 °C
• Boiling Point: 397.2°C at 760 mmHg
• Flash Point: 194°C
• Appearance: /
• Density: 1.106±0.06 g/cm3(Predicted)
• Vapor Pressure: 1.07E-06mmHg at 25°C
• PKA: 4.03±0.10(Predicted)
• CAS DataBase Reference: 3-(BENZYLOXY)-O-TOLUIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(BENZYLOXY)-O-TOLUIDINE(65361-82-2)
• EPA Substance Registry System: 3-(BENZYLOXY)-O-TOLUIDINE(65361-82-2)

Safety Data

• Hazardous Substances Data: 65361-82-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H15NO.ClH/c1-11-13(15)8-5-9-14(11)16-10-12-6-3-2-4-7-12;/h2-9H,10,15H2,1H3;1H

Upstream product

• 20876-37-3 2-benzyloxy-6-nitrotoluene 
• 5460-31-1 3-nitro-o-cresol 
• 100-39-0 benzyl bromide 

Downstream Products

• 850364-08-8 4-(benzyloxy)-1H-indazole 
• 669077-49-0 AG₀₃₅₀₂₉ 
• 871339-61-6 1,1-dimethylethyl 4-(3-{[2-(diethylamino)ethyl]oxy}-2-methylphenyl)piperazine-1-carboxylate 
• 871339-59-2 1,1-dimethylethyl 4-{2-methyl-3-[(phenylmethyl)oxy]phenyl}piperazine-1-carboxylate 
• 871464-78-7 N,N-diethyl-2-[(2-methyl-3-piperazin-1-ylphenyl)oxy]ethanamine 
• 871339-60-5 1,1-dimethylethyl 4-(3-hydroxy-2-methylphenyl)piperazine-1-carboxylate 
• 65361-83-3 (3-acetamino-2-methyl-phenyl)-benzyl ether 
• 871339-58-1 1-(3-(benzyloxy)-2-methylphenyl)piperazine 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.

PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.