Indolizine, octahydro-2,2,5-trimethyl-, (5R,8aR)-rel- (9CI)

Base Information

Chemical Name:Indolizine, octahydro-2,2,5-trimethyl-, (5R,8aR)-rel- (9CI)
CAS No.:669073-79-4
Molecular Formula:C11H21N
Molecular Weight:167.29
Hs Code.:
Mol file:669073-79-4.mol

Synonyms:Indolizine, octahydro-2,2,5-trimethyl-, (5R,8aR)-rel- (9CI)

Suppliers and Price of Indolizine, octahydro-2,2,5-trimethyl-, (5R,8aR)-rel- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of Indolizine, octahydro-2,2,5-trimethyl-, (5R,8aR)-rel- (9CI)

Chemical Property:

Boiling Point:197.4±8.0 °C(Predicted)
PKA:10.72±0.60(Predicted)
Density:0.92±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Indolizine, octahydro-2,2,5-trimethyl-, (5R,8aR)-rel- (9CI)

There total 7 articles about Indolizine, octahydro-2,2,5-trimethyl-, (5R,8aR)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 669073-75-0
trans-2,2-dimethyl-4,8-nonadieneylamine

: 669073-79-4
(+/-)-(5RS,8aRS)-2,2,5-trimethyl-octahydroindolizine

Guidance literature:: With [Me2Si(η⁵-C5Me4)(t-BuN)]SmCH(TMS)2; In benzene; at 125 ℃; for 48h;
DOI:10.1021/jo035417c

Reference yield:

: 821-09-0
n-Pent-4-enyl alcohol

: 669073-79-4
(+/-)-(5RS,8aRS)-2,2,5-trimethyl-octahydroindolizine

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

2.1: 52 g / CH₂Cl₂ / 2 h / 20 °C

3.1: 97 percent / DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

4.1: Et₃N / CH₂Cl₂ / 0 °C

5.1: LDA / tetrahydrofuran / 1 h / -78 - 0 °C

5.2: 3.6 g / CH₂Cl₂ / -78 - 20 °C

6.1: 90 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

7.1: 59 percent / [Me2Si(η⁵-C5Me4)(t-BuN)]SmN(TMS)2 / benzene / 48 h / 125 °C

With lithium aluminium tetrahydride; oxalyl dichloride; [Me2Si(η⁵-C5Me4)(t-BuN)]SmCH(TMS)2; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 1.1: Swern oxidation / 2.1: Wittig reaction;
DOI:10.1021/jo035417c

Reference yield:

: 2100-17-6
4-pentenal

: 669073-79-4
(+/-)-(5RS,8aRS)-2,2,5-trimethyl-octahydroindolizine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 52 g / CH₂Cl₂ / 2 h / 20 °C

2.1: 97 percent / DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

3.1: Et₃N / CH₂Cl₂ / 0 °C

4.1: LDA / tetrahydrofuran / 1 h / -78 - 0 °C

4.2: 3.6 g / CH₂Cl₂ / -78 - 20 °C

5.1: 90 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

6.1: 59 percent / [Me2Si(η⁵-C5Me4)(t-BuN)]SmN(TMS)2 / benzene / 48 h / 125 °C

With lithium aluminium tetrahydride; [Me2Si(η⁵-C5Me4)(t-BuN)]SmCH(TMS)2; diisobutylaluminium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 1.1: Wittig reaction;
DOI:10.1021/jo035417c