Carbamic acid, (3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

Chemical Name:Carbamic acid, (3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
CAS No.:603310-25-4
Molecular Formula:C10H13FN2O2
Molecular Weight:212.2208232
Hs Code.:
Mol file:603310-25-4.mol

Synonyms:Carbamic acid, (3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

Suppliers and Price of Carbamic acid, (3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
Carbamicacid,N-(3-fluoro-2-pyridinyl)-,1,1-dimethylethylester 95
10g
$ 1925.00

Total 3 raw suppliers

Chemical Property of Carbamic acid, (3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

PSA：51.22000
LogP:2.64070

Purity/Quality:

99%+ ^*data from raw suppliers

Carbamicacid,N-(3-fluoro-2-pyridinyl)-,1,1-dimethylethylester 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Carbamic acid, (3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-65-0
tert-butyl alcohol

: lithium 3-fluoropyridine-2-carboxylate

: 603310-25-4
N-[tert-butoxycarbonyl]-2-amino-3-fluoro-pyridine

Guidance literature:: With diphenyl phosphoryl azide; for 3h; Heating / reflux;

Reference yield:

: 372-47-4
3-Fluoropyridine

: tert-butyl ((3-chloro-5,6-dicyanopyrazin-2-yl)oxy)carbamate

: 603310-25-4
N-[tert-butoxycarbonyl]-2-amino-3-fluoro-pyridine

: 342603-20-7
(5-fluoro-3-pyridinyl)carbamic acid 1,1-dimethylethyl ester

Guidance literature:: 3-Fluoropyridine; tert-butyl ((3-chloro-5,6-dicyanopyrazin-2-yl)oxy)carbamate; With N,O-bis-(trimethylsilyl)-acetamide; In 1,4-dioxane; at 80 ℃; for 3h;

With acetic acid; zinc; In 1,4-dioxane; at 20 ℃; for 3h; Overall yield = 83 percentChromat.; chemoselective reaction;
DOI:10.1021/jacs.0c03537

Reference yield:

: 36016-38-3
tert-Butyl N-hydroxycarbamate

: 603310-25-4
N-[tert-butoxycarbonyl]-2-amino-3-fluoro-pyridine

: 342603-20-7
(5-fluoro-3-pyridinyl)carbamic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.67 h / -20 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / 1,4-dioxane / 3 h / 80 °C

2.2: 3 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jacs.0c03537