1-N-BENZYL-PROLINE

Base Information

• Chemical Name: 1-N-BENZYL-PROLINE
• CAS No.: 60169-72-4
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Hs Code.: 2933990090
• Mol file: 60169-72-4.mol

Synonyms:Pyrrolidine,1-benzyl;N-benzylproline;benzyl pyrrolidine;

Chemical Property of 1-N-BENZYL-PROLINE

Chemical Property:

• Melting Point: 170-170.5 °C
• Boiling Point: 343.1±35.0 °C(Predicted)
• PKA: 2.35±0.20(Predicted)
• PSA: 40.54000
• Density: 1.205±0.06 g/cm3(Predicted)
• LogP: 1.67350
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Benzylproline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BENZYL-PROLINE

There total 4 articles about 1-N-BENZYL-PROLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzyl bromide (100-39-0) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 1-benzyl-pyrrolidine-2-carboxylic acid (60169-72-4)

Guidance literature:

With potassium hydroxide; In chloroform; isopropyl alcohol;

Reference yield: 85.0%

benzyl chloride (100-44-7) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 1-benzyl-pyrrolidine-2-carboxylic acid (60169-72-4)

Guidance literature:

benzyl chloride; rac-Pro-OH; With potassium hydroxide; In isopropyl alcohol; at 40 ℃;

With hydrogenchloride; In water; isopropyl alcohol; pH=4 - 5;

DOI:10.1016/j.tet.2010.08.021

Reference yield: 27.0%

benzyl chloride (100-44-7) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 1-benzyl-pyrrolidine-2-carboxylic acid (60169-72-4)

Guidance literature:

With sodium carbonate; In ethanol; for 3h; Heating;

upstream raw materials:

benzyl chloride

L-proline

benzyl bromide

rac-Pro-OH

Downstream raw materials:

1-benzylpyrrolidine-2-carboxylic acid methyl ester

(1-benzylpyrrolidin-2-yl)phosphonic acid diethyl ester

3-(1-benzylpyrrolidin-2-yl)-2-methyl-1H-indole

1-benzyl-2-(dec-1-yn-1-yl)pyrrolidine