N-(tert-Butoxycarbonyl)isoleucylglycine

Base Information

• Chemical Name: N-(tert-Butoxycarbonyl)isoleucylglycine
• CAS No.: 16257-05-9
• Molecular Formula: C13H24 N2 O5
• Molecular Weight: 288.344
• DSSTox Substance ID: DTXSID80562131
• Mol file: 16257-05-9.mol

Synonyms:N-(tert-Butoxycarbonyl)isoleucylglycine;2-[[3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]acetic acid;DTXSID80562131;STR09461;AKOS037655930;2-(2-{[(tert-butoxy)carbonyl]amino}-3-methylpentanamido)acetic acid

Chemical Property of N-(tert-Butoxycarbonyl)isoleucylglycine

Chemical Property:

• Boiling Point: 499.6±30.0 °C(Predicted)
• PKA: 3.42±0.10(Predicted)
• PSA: 104.73000
• Density: 1.122±0.06 g/cm3(Predicted)
• LogP: 1.90840
• Storage Temp.: -15°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 288.16852187
• Heavy Atom Count: 20
• Complexity: 362

Purity/Quality:

≥ 95% ^*data from raw suppliers

BOC-Ile-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NCC(=O)O)NC(=O)OC(C)(C)C

Technology Process of N-(tert-Butoxycarbonyl)isoleucylglycine

There total 5 articles about N-(tert-Butoxycarbonyl)isoleucylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

BOC-Ile-Gly-OMe (16257-04-8) → 2-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)acetic acid (16257-05-9)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

DOI:10.3390/molecules24193424

Reference yield:

2-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)acetic aid ethyl ester (56439-59-9) → 2-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)acetic acid (16257-05-9)

Guidance literature:

With lithium hydroxide monohydrate; water; In ethanol; at 20 ℃; for 5h;

Reference yield:

N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) → 2-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)acetic acid (16257-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / acetonitrile / 0 °C

2: aq. NaOH / methanol

With sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; acetonitrile;

DOI:10.1002/cber.19671001017

upstream raw materials:

BOC-Ile-Gly-OMe

N-(tert-butoxy)carbonyl-L-isoleucine N-hydroxysuccinimide ester

glycine

N-(tert-butyloxycarbonyl)-L-isoleucine

Downstream raw materials:

Boc-Ile-Gly-N-Me-D-Phe-Pro-OM

tert.-Butyloxycarbonyl-Ile-Gly-(p-nitro-phenylester)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 16257-05-9 BOC-ILE-GLY-OH

Send

Send

Metric Ton KG G Pound L ML

Send

Send