Benzamide, N-[(1R,2R)-2-[(1R)-1-hydroxyethyl]-1-methylcyclopentyl]-, rel-

Base Information

Chemical Name:Benzamide, N-[(1R,2R)-2-[(1R)-1-hydroxyethyl]-1-methylcyclopentyl]-, rel-
CAS No.:591742-09-5
Molecular Formula:C15H21NO2
Molecular Weight:247.33
Hs Code.:
Mol file:591742-09-5.mol

Synonyms:Benzamide, N-[(1R,2R)-2-[(1R)-1-hydroxyethyl]-1-methylcyclopentyl]-, rel-

Suppliers and Price of Benzamide, N-[(1R,2R)-2-[(1R)-1-hydroxyethyl]-1-methylcyclopentyl]-, rel-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, N-[(1R,2R)-2-[(1R)-1-hydroxyethyl]-1-methylcyclopentyl]-, rel-

Chemical Property:

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Technology Process of Benzamide, N-[(1R,2R)-2-[(1R)-1-hydroxyethyl]-1-methylcyclopentyl]-, rel-

There total 4 articles about Benzamide, N-[(1R,2R)-2-[(1R)-1-hydroxyethyl]-1-methylcyclopentyl]-, rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 98-88-4
benzoyl chloride

: (R)-1-((1R,2R)-2-Amino-2-methyl-cyclopentyl)-ethanol

: 591742-09-5
N-[(1S,2S)-2-((S)-1-Hydroxy-ethyl)-1-methyl-cyclopentyl]-benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol035046m

Reference yield:

: 74810-53-0
cis-6-octen-2-one

: 591742-09-5
N-[(1S,2S)-2-((S)-1-Hydroxy-ethyl)-1-methyl-cyclopentyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzene / 20 h / Heating

2.1: TEA / CH₂Cl₂ / 0 - 20 °C

2.2: 3 Angstroem molecular sieves; TFA / 1,2-dichloro-ethane / 0 - 20 °C

2.3: BF₃ etherate / 1,2-dichloro-ethane; methoxybenzene / 18 h / Heating

3.1: 94 percent / H₂ / Pd(OH)2/C / ethyl acetate / 15 h / 100 °C / 54300.5 Torr

4.1: 79 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With TEA; hydrogen; triethylamine; palladium dihydroxide; In dichloromethane; ethyl acetate; benzene; 2.2: intramolecular Diels-Alder reaction / 2.3: intramolecular Diels-Alder reaction;
DOI:10.1021/ol035046m

Reference yield:

: (4S,4aS,7aS)-4,7a-Dimethyl-2-phenyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[d][1,3]oxazine

: 591742-09-5
N-[(1S,2S)-2-((S)-1-Hydroxy-ethyl)-1-methyl-cyclopentyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / H₂ / Pd(OH)2/C / ethyl acetate / 15 h / 100 °C / 54300.5 Torr

2: 79 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium dihydroxide; In dichloromethane; ethyl acetate;
DOI:10.1021/ol035046m