3(2H)-Pyridazinone, 5-hydroxy-2-methyl-4-(2-methylphenyl)- (9CI)

Base Information

Chemical Name:3(2H)-Pyridazinone, 5-hydroxy-2-methyl-4-(2-methylphenyl)- (9CI)
CAS No.:503454-50-0
Molecular Formula:C12 H12 N2 O2
Molecular Weight:216.23588
Hs Code.:2933990090
Mol file:503454-50-0.mol

Synonyms:3(2H)-Pyridazinone, 5-hydroxy-2-methyl-4-(2-methylphenyl)- (9CI)

Suppliers and Price of 3(2H)-Pyridazinone, 5-hydroxy-2-methyl-4-(2-methylphenyl)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3(2H)-Pyridazinone, 5-hydroxy-2-methyl-4-(2-methylphenyl)- (9CI)

Chemical Property:

Boiling Point:367.4±52.0 °C(Predicted)
PKA:4.50±1.00(Predicted)
PSA：55.12000
Density:1.22±0.1 g/cm3(Predicted)
LogP:1.46130

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3(2H)-Pyridazinone, 5-hydroxy-2-methyl-4-(2-methylphenyl)- (9CI)

There total 3 articles about 3(2H)-Pyridazinone, 5-hydroxy-2-methyl-4-(2-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 335349-37-6
5-methoxy-2-methyl-4-(2-methylphenyl)-3(2H)-pyridazinone

: 503454-50-0
5-hydroxy-2-methyl-4-(2-methylphenyl)pyridazin-3(2H)-one

Guidance literature:: With potassium hydroxide; In water; at 110 ℃; for 24h;
DOI:10.1016/S0040-4020(02)01285-1

Reference yield:

: 16419-60-6
2-Methylphenylboronic acid

: 503454-50-0
5-hydroxy-2-methyl-4-(2-methylphenyl)pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / bis(triphenylphosphino) palladium dichloride

2: 40 percent / BBr₃ / CH₂Cl₂

With bis-triphenylphosphine-palladium(II) chloride; boron tribromide; In dichloromethane; 1: Suzuki coupling reaction;
DOI:10.1002/jhet.5570420310

Reference yield:

: 186792-13-2
4-bromo-5-methoxy-2-methylpyridazin-3(2H)-one

: 503454-50-0
5-hydroxy-2-methyl-4-(2-methylphenyl)pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / bis(triphenylphosphino) palladium dichloride

2: 40 percent / BBr₃ / CH₂Cl₂

With bis-triphenylphosphine-palladium(II) chloride; boron tribromide; In dichloromethane; 1: Suzuki coupling reaction;
DOI:10.1002/jhet.5570420310