2,6-DIMETHOXYPYRIDINE-3-METHANOL

Base Information

• Chemical Name: 2,6-DIMETHOXYPYRIDINE-3-METHANOL
• CAS No.: 562840-47-5
• Molecular Formula: C₈H₁₁NO₃
• Molecular Weight: 169.18
• Mol file: 562840-47-5.mol

Synonyms:(2,6-Dimethoxypyridin-3-yl)methanol;2,6-Dimethoxypyridine-3-methanol;

Chemical Property of 2,6-DIMETHOXYPYRIDINE-3-METHANOL

Chemical Property:

• Vapor Pressure: 0.00322mmHg at 25°C
• Melting Point: 56-60°C
• Refractive Index: 1.523
• Boiling Point: 271.2 °C at 760 mmHg
• Flash Point: 117.8 °C
• PSA: 51.58000
• Density: 1.17 g/cm³
• LogP: 0.59110

Purity/Quality:

98%Min ^*data from raw suppliers

2,6-Dimethoxypyridine-3-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIMETHOXYPYRIDINE-3-METHANOL

There total 6 articles about 2,6-DIMETHOXYPYRIDINE-3-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,6-dimethoxypyridine-3-carboxaldehyde (58819-72-0) → (2,6-dimethoxypyridin-3-yl)methanol (562840-47-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2006.12.034

Reference yield: 83.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,6-dimethoxypyridine-3-boronic acid (221006-70-8) → (2,6-dimethoxypyridin-3-yl)methanol (562840-47-5)

Guidance literature:

With C₆₂H₇₄Cl₂N₄Pd₂S₂; caesium carbonate; In tetrahydrofuran; water; at 70 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1002/cctc.202001464

Reference yield: 79.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2,6-dimethoxypyridine (1188303-83-4) → (2,6-dimethoxypyridin-3-yl)methanol (562840-47-5)

Guidance literature:

With di-μ-chloro-bis{2-[3-(2,6-diisopropylphenyl)imidazolin-2-ylidene]-(3-phenylthio)phenyl-κ²C,C’}dipalladium(II); caesium carbonate; In tetrahydrofuran; water; at 70 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201400845

upstream raw materials:

2,6-dimethoxypyridine-3-carboxaldehyde

3-bromo-2,6-dimethoxypyridine

2,6-dimethoxypyridine

2,6-dimethoxynicotinic acid ethyl ester

Downstream raw materials:

C₈H₁₀NO₂Br

C₂₂H₃₁NO₄Si

C₂₂H₃₁NO₄Si

methyl 2,6-dimethoxypyridine-3-carboxylate

Refernces

• 1、 Yamamoto, Tetsuya,Zhumagazin, Azamat,Furusawa, Takuma,Tanaka, Ryoji,Yamakawa, Tetsu,Oe, Yohei,Ohtab, Tetsuo. "Palladium-catalyzed hydroxymethylation of aryl-and heteroarylboronic acids using aqueous formaldehyde". supporting information. p. 3525 - 3529. Retrieved 2015/01/09.
• 2、 -. "NITROGENOUS CYCLIC KETONE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE". Page 63. . Retrieved 2010/02/08.