Cyclopent[b]indol-3(2H)-one, 1,4-dihydro-2,4-dimethyl- (9CI)

Base Information

• Chemical Name: Cyclopent[b]indol-3(2H)-one, 1,4-dihydro-2,4-dimethyl- (9CI)
• CAS No.: 566149-87-9
• Molecular Formula: C13H13NO
• Molecular Weight: 199.24842
• Mol file: 566149-87-9.mol

Synonyms:Cyclopent[b]indol-3(2H)-one, 1,4-dihydro-2,4-dimethyl- (9CI)

Chemical Property of Cyclopent[b]indol-3(2H)-one, 1,4-dihydro-2,4-dimethyl- (9CI)

Chemical Property:

• PSA: 22.00000
• LogP: 2.55320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopent[b]indol-3(2H)-one, 1,4-dihydro-2,4-dimethyl- (9CI)

There total 4 articles about Cyclopent[b]indol-3(2H)-one, 1,4-dihydro-2,4-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-methyl-1-(1-methyl-1H-indol-2-yl)prop-2-en-1-one → 2,4-dimethyl-1,4-dihydrocyclopenta[b]indol-3(2H)-one (566149-87-9)

Guidance literature:

at 60 ℃; for 16h; diastereoselective reaction; Green chemistry;

DOI:10.1039/c9gc03465j

Reference yield: 20.0%

1-methylindole (603-76-9) + poly(methacrylic acid) (79-41-4,25087-26-7,50867-57-7) → 2,4-dimethyl-1,4-dihydrocyclopenta[b]indol-3(2H)-one (566149-87-9)

Guidance literature:

With Eaton′s Reagent; at 70 ℃; for 2h; Inert atmosphere;

Reference yield:

2-methyl-1-(1-methyl-1H-indol-2-yl)prop-2-en-1-ol → 2,4-dimethyl-1,4-dihydrocyclopenta[b]indol-3(2H)-one (566149-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: 16 h / 60 °C / Green chemistry

With manganese(IV) oxide; In dichloromethane; 2: |Nazarov Cyclization;

DOI:10.1039/c9gc03465j

upstream raw materials:

1-methylindole

poly(methacrylic acid)