5-(Thiophen-3-yl)furan-2-carboxylic acid

Base Information

Chemical Name:5-(Thiophen-3-yl)furan-2-carboxylic acid
CAS No.:560993-95-5
Molecular Formula:C9H6O3S
Molecular Weight:194.21
Hs Code.:
DSSTox Substance ID:DTXSID50400551
Wikidata:Q82203559
Mol file:560993-95-5.mol

Synonyms:5-(thiophen-3-yl)furan-2-carboxylic acid;560993-95-5;5-thiophen-3-ylfuran-2-carboxylic Acid;5-Thiophen-3-yl-furan-2-carboxylic acid;F2167-0888;5-(3-thienyl)-2-furoic acid;DTXSID50400551;MFCD06740286;AKOS002666057;FS-1985;SB61986;5-(thiophen-3-yl)furan-2-carboxylicacid;CS-0453608;EN300-239526;F21142

Suppliers and Price of 5-(Thiophen-3-yl)furan-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-(Thiophen-3-yl)furan-2-carboxylicacid 95+%
1g
$ 550.00

CHESS?
CA024776:5-Thiophen-3-yl-furan-2-carboxylicacid 97
5 g
$ 1068.00

Chemenu
5-(Thiophen-3-yl)furan-2-carboxylicacid 95%
1g
$ 519.00

Arctom
5-(Thiophen-3-yl)furan-2-carboxylicacid
1g
$ 602.00

Total 4 raw suppliers

Chemical Property of 5-(Thiophen-3-yl)furan-2-carboxylic acid

Chemical Property:

PSA：78.68000
LogP:2.70630
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:194.00376522
Heavy Atom Count:13
Complexity:207

Purity/Quality:

97% ^*data from raw suppliers

5-(Thiophen-3-yl)furan-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC=C1C2=CC=C(O2)C(=O)O
Uses 5-(Thiophen-3-yl)furan-2-carboxylic acid is used as a reactant in the palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of potassium aryl- and heteroaryltrifluoroborates.

Technology Process of 5-(Thiophen-3-yl)furan-2-carboxylic acid

There total 3 articles about 5-(Thiophen-3-yl)furan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1276591-90-2
C₁₀H₈O₃S

: 560993-95-5
5-(3'-thienyl)furan-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; for 24h; Inert atmosphere;
DOI:10.1002/cmdc.201000475

Reference yield: 80.0%

: 585-70-6
5-bromo-furan-2-carboxylic acid

: potassium 3-thiophenetrifluoroborate

: 560993-95-5
5-(3'-thienyl)furan-2-carboxylic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In ethanol; for 10h; Heating;
DOI:10.1021/jo0342368

Reference yield:

: 2527-99-3
methyl 5-bromo-2-furoate

: 560993-95-5
5-(3'-thienyl)furan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 90 °C / Inert atmosphere

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 24 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: Suzuki-Miyaura cross coupling;
DOI:10.1002/cmdc.201000475