80866-76-8

Basic information

• Product Name: 3-METHYL-2-NITROBENZYL ALCOHOL
• Synonyms: 2-Nitro-3-methylbenzenemethanol;(3-Methyl-2-nitrophenyl)Methanol;(3-Methyl-2-nitrophenyl)methanol, (2-Nitro-m-tolyl)methanol;3-Methyl-2-nitrobenzyl alcohol 98%;3-METHYL-2-NITROBENZYL ALCOHOL;3-Methyl-2-nitrobenzyl alcohol ,98%
• CAS NO: 80866-76-8
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• EINECS: 279-579-9
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;C7 to C8;Oxygen Compounds
• Mol File: 80866-76-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 48-50 °C(lit.)
• Boiling Point: 295.73°C (rough estimate)
• Flash Point: >230 °F
• Appearance: yellow-brown to brownish crystalline solid
• Density: 1.2917 (rough estimate)
• Vapor Pressure: 0.000806mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• Storage Temp.: 2-8°C
• PKA: 14.04±0.10(Predicted)
• CAS DataBase Reference: 3-METHYL-2-NITROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-2-NITROBENZYL ALCOHOL(80866-76-8)
• EPA Substance Registry System: 3-METHYL-2-NITROBENZYL ALCOHOL(80866-76-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 80866-76-8(Hazardous Substances Data)

Usage

Chemical Properties

yellow-brown to brownish crystalline solid

Uses

3-Methyl-2-nitrobenzyl alcohol was used as starting reagent in the synthesis of 7-formyl-indole.

General Description

3-Methyl-2-nitrobenzyl alcohol undergoes condensation with N,N-dimethylformamide dimethyl acetal followed by catalytic hydrogenation to yield 7-hydroxymethyl-indole.

InChI:InChI=1/C8H9NO3/c1-6-3-2-4-7(5-10)8(6)9(11)12/h2-4,10H,5H2,1H3

Upstream product

• 67-56-1 methanol 
• 5471-82-9 methyl 3-methyl-2-nitrobenzoate 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 18710-86-6 2-(3-methyl-2-nitrophenyl)acetic acid 
• 50424-93-6 3-methyl-2-nitrobenzoyl chloride 

Downstream Products

• 102781-39-5 2-(3-methyl-2-nitrophenyl)ethan-1-ol 
• 18710-86-6 2-(3-methyl-2-nitrophenyl)acetic acid 

Relevant articles and documents

Pendant Alkoxy Groups on N-Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde

Hydrogen-transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β-unsaturated aldehyde forms a conjugated Breslow intermediate. This is a critical step affecting the efficiency of the NHC-catalyzed γ-butyrolactone formation via homoenolate addition to aryl aldehydes. A novel type of imidazolylidene catalyst with pendant alkoxy groups on the ortho-N-aryl groups is described. Catalyst of this sort facilitates the formation of the conjugated Breslow intermediate. Studies of the rate constants for homoenolate annulation affording γ-butyrolactones, reveal that introduction of the oxygen atoms in the appropriate position of the N-aryl substituents can increase the efficiency of imidazolylidene catalysts. Structural and mechanistic studies revealed that pendant alkoxy groups can be located close to the proton of the tetrahedral intermediate, thereby facilitating the proton transfer.

Rh2(II)-catalyzed selective aminomethylene migration from styryl azides

Rh2(II)-Carboxylate complexes were discovered to promote the selective migration of aminomethylenes in β,β-disubstituted styryl azides to form 2,3-disubstituted indoles. Mechanistic data are also presented that suggest that the migration occurs stepwise before diffusion of the iminium ion.

PROCESS FOR PRODUCING (2-NITROPHENYL)ACETONITRILE DERIVATIVE AND INTERMEDIATE THEREFOR

The present invention lies in a process for producing a compound represented by the following formula [IV], which comprises the following steps (1) to (3), as well as in an intermediate therefor.(1) A step which comprises reacting a compound represented by the following formula [I] with a compound represented by the following formula [VI] or with a mixture of a compound represented by the following formula [VII] and a compound represented by the following formula [VIII] to obtain a compound represented by the following formula [IX], and hydrolyzing the compound represented by the formula [IX] under acidic conditions to obtain a compound represented by the following formula [II].(2) A step which comprises reacting the compound represented by the formula [II] with hydroxylamine to obtain a compound represented by the following formula [III].(3) A step which comprises dehydrating the compound represented by the formula [III] to obtain a compound represented by the formula [IV].