(S)-tert-Butyl (1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate

Base Information

• Chemical Name: (S)-tert-Butyl (1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate
• CAS No.: 2766-42-9
• Molecular Formula: C8H17 N3 O4
• Molecular Weight: 219.2383
• European Community (EC) Number: 965-329-2
• Mol file: 2766-42-9.mol

Synonyms:32988-38-8;(S)-tert-Butyl (1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate;tert-butyl N-[(2S)-1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl]carbamate;TERT-BUTYL N-[(1S)-1-(HYDRAZINECARBONYL)-2-HYDROXYETHYL]CARBAMATE;2766-42-9;SCHEMBL26206757;G57842;EN300-23049853;tert-Butyl N-[(S)-1-hydrazinecarbonyl-2-hydroxyethyl]carbamate;(S)-tert-Butyl(1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate;tert-Butyl (S)-(1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate

Chemical Property of (S)-tert-Butyl (1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate

Chemical Property:

• Vapor Pressure: 1.98E-10mmHg at 25°C
• Boiling Point: 460.8°C at 760 mmHg
• Flash Point: 232.5°C
• Density: 1.215g/cm³
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 219.12190603
• Heavy Atom Count: 15
• Complexity: 237

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CO)C(=O)NN
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CO)C(=O)NN

Technology Process of (S)-tert-Butyl (1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate

There total 3 articles about (S)-tert-Butyl (1-hydrazinyl-3-hydroxy-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

N-tert-butyloxycarbonyl-L-serine methyl ester (2766-43-0) → tert-butyl (S)-(1-hydrazineyl-3-hydroxy-1-oxopropan-2-yl)carbamate (2766-42-9)

Guidance literature:

With hydrazine hydrate; In methanol; at 50 ℃;

Reference yield: 90.0%

N-tert-butoxycarbonylserine methyl ester (69942-12-7) → N-tert.-Butoxycarbonyl-serinhydrazid (2766-42-9,16882-36-3,32988-38-8)

Guidance literature:

With hydrazine hydrate; at 0 - 20 ℃; for 17h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-tert.-Butoxycarbonyl-serinhydrazid (2766-42-9,16882-36-3,32988-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0.5 h / 0 - 5 °C

1.2: 3 h / 0 - 5 °C / pH 8 - 10

2.1: hydrazine hydrate / 17 h / 0 - 20 °C

With hydrazine hydrate; sodium hydrogencarbonate; In tetrahydrofuran; water;

upstream raw materials:

N-tert-butyloxycarbonyl-L-serine methyl ester

di-tert-butyl dicarbonate

N-tert-butoxycarbonylserine methyl ester

Downstream raw materials:

C₁₆H₂₃N₃O₄

C₁₆H₂₃N₃O₅

C₁₇H₂₅N₃O₅

C₁₆H₂₃N₃O₅