Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-propynyl ester (9CI)

Base Information

• Chemical Name: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-propynyl ester (9CI)
• CAS No.: 537710-06-8
• Molecular Formula: C10H15NO4
• Molecular Weight: 213.2304
• Mol file: 537710-06-8.mol

Synonyms:Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-propynyl ester (9CI)

Chemical Property of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-propynyl ester (9CI)

Chemical Property:

• PSA: 64.63000
• LogP: 1.07840

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-propynyl ester (9CI)

There total 2 articles about Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-propynyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

BOC-glycine (4530-20-5) + propargyl bromide (106-96-7) → N-Boc-glycine propargyl ester (537710-06-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/anie.201610273

Reference yield: 63.0%

BOC-glycine (4530-20-5) + propargyl alcohol (107-19-7) → N-Boc-glycine propargyl ester (537710-06-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201604247 DOI:10.1039/c7cc01934c

Reference yield: 59.0%

N-Boc-glycine propargyl ester (537710-06-8) + 3-Phenylpropan-1-amine (2038-57-5) → N-Boc-glycine-3-phenylpropylamide

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1002/chem.201604247

upstream raw materials:

BOC-glycine

propargyl alcohol

propargyl bromide

Downstream raw materials:

2S-[[(1,1-dimethylethoxy) carbonyl]amino]-N-[2R-hydroxy-3-[[(1,3-benzodioxol-5-yl)sulfonyl](2-methylpropyl)amino]-1S-(phenylmethyl) propyl]pent-4-ynamide

cyclohexylcarbamoylmethylcarbamic acid t-butyl ester

Boc-glycine-benzylamide

tert-butyl N-{[(2-phenylethyl)carbamoyl]methyl}carbamate