((R)-2-CHLORO-PROPYL)-BENZENE

Base Information

• Chemical Name: ((R)-2-CHLORO-PROPYL)-BENZENE
• CAS No.: 55449-46-2
• Molecular Formula: C9H11Cl
• Molecular Weight: 154.639
• Mol file: 55449-46-2.mol

Synonyms:((R)-2-CHLORO-PROPYL)-BENZENE

Chemical Property of ((R)-2-CHLORO-PROPYL)-BENZENE

Chemical Property:

• Vapor Pressure: 0.27mmHg at 25°C
• Melting Point: -43.35°C (estimate)
• Refractive Index: 1.513
• Boiling Point: 211.1°C at 760 mmHg
• Flash Point: 79.7°C
• PSA: 0.00000
• Density: 1.027g/cm³
• LogP: 2.85640

Purity/Quality:

98%Min ^*data from raw suppliers

((R)-2-CHLORO-PROPYL)-BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ((R)-2-CHLORO-PROPYL)-BENZENE

There total 19 articles about ((R)-2-CHLORO-PROPYL)-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R)-1-phenyl-propan-2-ol (1572-95-8,14898-87-4) → (+)-2-chloro-1-phenylpropane (10304-81-1,55449-46-2,116698-42-1,16583-73-6)

Guidance literature:

With pyridine; bis(trichloromethyl) carbonate; In dichloromethane; at 0 ℃; Reflux;

DOI:10.1021/jo400341n

Reference yield: 74.0%

(S)-1-phenylpropan-2-ol (1517-68-6,14898-87-4) → (-)-2-chloro-1-phenylpropane (55449-46-2)

Guidance literature:

With pyridine; thionyl chloride; In chloroform; at 0 - 60 ℃; for 2.5h;

DOI:10.1016/j.tetlet.2013.02.079

Reference yield: 70.0%

(+)-1-chloro-2-phenylpropane (55394-72-4) → (-)-2-chloro-1-phenylpropane (55449-46-2)

Guidance literature:

With 1,1-dichloroethane; iron(III) chloride; at 65 ℃; for 2h;

DOI:10.1246/bcsj.56.1089

upstream raw materials:

(-)-1-phenyl-2-propanol

ethylmagnesium chloride

(S)-1-phenylpropan-2-ol

(R)-(-)-1-phenyl-2-phenyltelluropropane

Downstream raw materials:

1,1-diphenylpropane

(2R)-propane-1,2-diyldibenzene

Refernces

• 1、 Zhang, Junjie,Wang, Huanxia,Ma, Yun,Wang, Youming,Zhou, Zhenghong,Tang, Chuchi. "CaF2 catalyzed SN2 type chlorodehydroxylation of chiral secondary alcohols with thionyl chloride: A practical and convenient approach for the preparation of optically active chloroalkanes". . p. 2261 - 2263. Retrieved 2013/05/09.
• 2、 Ogura, Fumio,Okada, Yoshiharu,Nishimura, Naoko,Hamamoto, Kenichiro,Miyakawa, Makoto,Otsubo, Tetsuo,Aso, Yoshio,Inoue, Shinobu,Tsutsui, Koji. "Nucleophilic substitution of 1-phenyl-2-phenyl telluropropane to yield 2-halo-1-phenylpropanes". . p. 203 - 210. Retrieved 2007/10/03.