6-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 6-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 550998-52-2
• Molecular Formula: C10H7FO2S
• Molecular Weight: 210.22
• Hs Code.: 2934999090
• Mol file: 550998-52-2.mol

Synonyms:6-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property of 6-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000685mmHg at 25°C
• Refractive Index: 1.616
• Boiling Point: 308.3°C at 760 mmHg
• Flash Point: 140.3°C
• PSA: 54.54000
• Density: 1.355g/cm³
• LogP: 2.82700

Purity/Quality:

97% ^*data from raw suppliers

6-Fluoro-benzo[b]thiophene-2-carboxylicAcidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

There total 2 articles about 6-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,4-difluorobenzaldehyde (1550-35-2) + Methyl thioglycolate (2365-48-2) → 6-fluorobenzo[b]thiophene-2-carboxylic acid methyl ester (550998-52-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 15h;

DOI:10.1016/j.ejmech.2019.04.024

Reference yield: 67.0%

methyl 3-chloro-6-fluorobenzo[b]thiophene-2-carboxylate (21211-20-1) → 6-fluorobenzo[b]thiophene-2-carboxylic acid methyl ester (550998-52-2) + dimethyl 6,6'-difluoro-3,3'-bi(1-benzothiophene)-2,2'-dicarboxylate

Guidance literature:

With copper; In N,N-dimethyl-formamide; at 170 ℃; for 16h;

DOI:10.1135/cccc20031020

Reference yield: 94.0%

6-fluorobenzo[b]thiophene-2-carboxylic acid methyl ester (550998-52-2) → 6-fluorobenzo[b]thiophene-2-carboxylic acid (142329-23-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 50 ℃;

upstream raw materials:

methyl 3-chloro-6-fluorobenzo[b]thiophene-2-carboxylate

2,4-difluorobenzaldehyde

Methyl thioglycolate

Downstream raw materials:

6-fluorobenzo[b]thiophene-2-carboxylic acid

6-fluoro-benzo[b]thiophene