1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-, phenyl ester, (3R,4R)- (9CI)

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-, phenyl ester, (3R,4R)- (9CI)
• CAS No.: 612485-60-6
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.22522
• Mol file: 612485-60-6.mol

Synonyms:1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-, phenyl ester, (3R,4R)- (9CI)

Chemical Property of 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-, phenyl ester, (3R,4R)- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-, phenyl ester, (3R,4R)- (9CI)

There total 10 articles about 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-, phenyl ester, (3R,4R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

meso-N-phenoxycarbonyl-3,4-epoxypyrrolidine → (+/-)-N-phenoxycarbonyl-3,4-dihydroxypyrrolidine (612485-60-6,612485-56-0)

Guidance literature:

With trifluoroacetic acid; In chloroform; Heating;

DOI:10.1021/jo034628e

Reference yield: 65.0%

N-phenyloxycarbonyl-3-pyrroline (245036-98-0) → N-phenyloxycarbonyl-meso-3,4-dihydroxypyrrolidine (245036-99-1,612485-60-6,612485-56-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; potassium hexacyanoferrate(III); potassium osmate(VI); In water; tert-butyl alcohol; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(99)00518-9

Reference yield: 64.9%

phenyl chloroformate (1885-14-9) + (3R,4R)-pyrrolidine-3,4-diol (186393-31-7) → (+)-(3R,4R)-N-phenoxycarbonyl-3,4-dihydroxypyrrolidine (612485-60-6,612485-56-0)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/jo034628e

upstream raw materials:

N-phenyloxycarbonyl-3-pyrroline

phenyl chloroformate

(3R,4R)-pyrrolidine-3,4-diol