ethyl 2-(2-chlorophenyl)-2,3-dihydro-1H-indole-3-carboxylate

Base Information

Chemical Name:ethyl 2-(2-chlorophenyl)-2,3-dihydro-1H-indole-3-carboxylate
CAS No.:500592-32-5
Molecular Formula:C₁₇H₁₄ClNO₂
Molecular Weight:299.757
Hs Code.:
DSSTox Substance ID:DTXSID00403057
Mol file:500592-32-5.mol

Synonyms:500592-32-5;DTXSID00403057

Suppliers and Price of ethyl 2-(2-chlorophenyl)-2,3-dihydro-1H-indole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of ethyl 2-(2-chlorophenyl)-2,3-dihydro-1H-indole-3-carboxylate

Chemical Property:

PSA：38.33000
LogP:4.29150
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:301.0869564
Heavy Atom Count:21
Complexity:376

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1C(NC2=CC=CC=C12)C3=CC=CC=C3Cl

Technology Process of ethyl 2-(2-chlorophenyl)-2,3-dihydro-1H-indole-3-carboxylate

There total 7 articles about ethyl 2-(2-chlorophenyl)-2,3-dihydro-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: ethyl (2Z)-3-(2-chlorophenyl)-3-hydroxy-2-(2-nitrophenyl)-2-propenoate

: 500592-32-5
ethyl 2-(2-chlorophenyl)-1H-indole-3-carboxylate

Guidance literature:: With iron; acetic acid; at 115 ℃;

Reference yield: 84.0%

: 2009-97-4
ethyl 2-diazo-3-oxobutanoate

: 35427-95-3,141356-94-7
N-(2-chlorobenzylidene)aniline N-oxide

: 500592-32-5
ethyl 2-(2-chlorophenyl)-1H-indole-3-carboxylate

Guidance literature:: With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; sodium acetate; In 1,2-dichloro-ethane; at 120 ℃; for 12h; Sealed tube;
DOI:10.1021/acs.joc.7b02105

Reference yield: 50.0%

: 623-73-4
diazoacetic acid ethyl ester

: 6833-13-2
2-chlorobenzanilide

: 500592-32-5
ethyl 2-(2-chlorophenyl)-1H-indole-3-carboxylate

Guidance literature:: 2-chlorobenzanilide; With 2-chloropyridine; 2,6-dichloropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

diazoacetic acid ethyl ester; In dichloromethane; at -30 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1021/ja805706r