(2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoic acid

Base Information

• Chemical Name: (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoic acid
• CAS No.: 59937-41-6
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.309
• DSSTox Substance ID: DTXSID70376143
• Wikidata: Q82164954
• Mol file: 59937-41-6.mol

Synonyms:59937-41-6;(2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoic acid;N-Boc-(2S,3S)-3-amino-2-hydroxy-3-phenyl-propionic acid;(2S,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoic acid;N-Boc-(2S,3S)-3-amino-2-hydroxy-3-phenylpropanoic acid;(2S,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid;SCHEMBL7087412;DTXSID70376143;MFCD07363511;AKOS015949919;PS-12821;CS-0357163;(2S,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoic acid

Chemical Property of (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoic acid

Chemical Property:

• PSA: 95.86000
• LogP: 2.08880
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 281.12632271
• Heavy Atom Count: 20
• Complexity: 344

Purity/Quality:

98%Min ^*data from raw suppliers

(2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(C1=CC=CC=C1)C(C(=O)O)O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](C1=CC=CC=C1)[C@@H](C(=O)O)O

Technology Process of (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoic acid

There total 4 articles about (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzylidene<(R)-(-)-α-methylbenzyl>amine N-oxide (127001-34-7) → (2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionic acid (59937-41-6,126252-53-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / ZnI₂ / acetonitrile; CH₂Cl₂ / 1 h / 20 °C

2: 74 percent / aq. HF / acetic acid / 50 °C

3: 1.) H₂, 2.) Et₃N / 1.) Pd(OH)2/C / 1.) MeOH, AcOH, 2.) MeOH, overnight

With hydrogen fluoride; hydrogen; triethylamine; zinc(II) iodide; palladium dihydroxide; In dichloromethane; acetic acid; acetonitrile;

DOI:10.1021/jo971009v

Reference yield:

benzaldehyde (100-52-7) → (2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionic acid (59937-41-6,126252-53-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / NaHCO₃, MgSO₄ / tetrahydrofuran / 20 °C

2: 98 percent / ZnI₂ / acetonitrile; CH₂Cl₂ / 1 h / 20 °C

3: 74 percent / aq. HF / acetic acid / 50 °C

4: 1.) H₂, 2.) Et₃N / 1.) Pd(OH)2/C / 1.) MeOH, AcOH, 2.) MeOH, overnight

With hydrogen fluoride; hydrogen; sodium hydrogencarbonate; magnesium sulfate; triethylamine; zinc(II) iodide; palladium dihydroxide; In tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;

DOI:10.1021/jo971009v

Reference yield:

C41H61NO4Si2 (195196-19-1) → (2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionic acid (59937-41-6,126252-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / aq. HF / acetic acid / 50 °C

2: 1.) H₂, 2.) Et₃N / 1.) Pd(OH)2/C / 1.) MeOH, AcOH, 2.) MeOH, overnight

With hydrogen fluoride; hydrogen; triethylamine; palladium dihydroxide; In acetic acid;

DOI:10.1021/jo971009v

upstream raw materials:

di-tert-butyl dicarbonate

(3S,4S)-4-hydroxy-3-phenyl-N-(1-phenylethyl)isoxazolidinone

N-Benzylidene<(R)-(-)-α-methylbenzyl>amine N-oxide

benzaldehyde

Downstream raw materials:

methyl (2S,3S)-2-hydroxy-3-(N-tert-butoxycarbonylamino)-3-phenylpropanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 59937-41-6 N-BOC-(2S,3S)-3-AMINO-2-HYDROXY-3-PHENYL-PROPIONIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send