2-FLUORO-5-NITRO-BENZOIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-FLUORO-5-NITRO-BENZOIC ACID TERT-BUTYL ESTER
• CAS No.: 526218-22-4
• Molecular Formula: C11H12FNO4
• Molecular Weight: 241.219
• Hs Code.: 2916399090
• Mol file: 526218-22-4.mol

Synonyms:TERT-BUTYL 2-FLUORO-5-NITROBENZOATE;2-FLUORO-5-NITRO-BENZOIC ACID TERT-BUTYL ESTER

Chemical Property of 2-FLUORO-5-NITRO-BENZOIC ACID TERT-BUTYL ESTER

Chemical Property:

• PSA: 72.12000
• LogP: 3.21240

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-5-nitro-benzoicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-5-NITRO-BENZOIC ACID TERT-BUTYL ESTER

There total 1 articles about 2-FLUORO-5-NITRO-BENZOIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-fluoro-5-nitrobenzoic acid (7304-32-7) → tert-butyl 2-fluoro-5-nitrobenzoate (526218-22-4)

Guidance literature:

dmap; In tetrahydrofuran; tert-butyl alcohol; for 25h;

Reference yield: 69.0%

tert-butyl 2-fluoro-5-nitrobenzoate (526218-22-4) + tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-(3-hydroxypropoxy)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate → tert-butyl 2-(3-(((2R,3R)-4-((tert-butoxycarbonyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-1-(4-fluoro-N-methylphenylsulfonamido)-3-methylbutan-2-yl)oxy)propoxy)-5-nitrobenzoate

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 40h; Molecular sieve; Inert atmosphere;

DOI:10.1021/jm500994n

Reference yield:

tert-butyl 2-fluoro-5-nitrobenzoate (526218-22-4) → tert-butyl 5-amino-2-fluorobenzoate (853070-30-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; for 6h;

upstream raw materials:

di-tert-butyl dicarbonate

2-fluoro-5-nitrobenzoic acid

Downstream raw materials:

tert-butyl 5-amino-2-fluorobenzoate

C₃₀H₄₇N₃O₁₀

C₂₁H₃₁N₃O₈

C₃₀H₄₇N₃O₁₀

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