Benzoic acid, 4-[(1-methylpropyl)amino]- (9CI)

Base Information

• Chemical Name: Benzoic acid, 4-[(1-methylpropyl)amino]- (9CI)
• CAS No.: 518336-10-2
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.2423
• Mol file: 518336-10-2.mol

Synonyms:Benzoic acid, 4-[(1-methylpropyl)amino]- (9CI)

Chemical Property of Benzoic acid, 4-[(1-methylpropyl)amino]- (9CI)

Chemical Property:

• PSA: 49.33000
• LogP: 2.66820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-[(1-methylpropyl)amino]- (9CI)

There total 3 articles about Benzoic acid, 4-[(1-methylpropyl)amino]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

SEC-BUTYLAMINE (33966-50-6) + 4-Bromobenzoic acid (586-76-5) → 4-N-sec-butylamino-benzoic acid (518336-10-2)

Guidance literature:

With lithium hexamethyldisilazane; palladium diacetate; (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine; In 1,2-dimethoxyethane; at 100 ℃; for 20h;

DOI:10.1021/ja077074w

Reference yield: 85.0%

SEC-BUTYLAMINE (33966-50-6) + para-chlorobenzoic acid (74-11-3) → 4-N-sec-butylamino-benzoic acid (518336-10-2)

Guidance literature:

With (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine; lithium hexamethyldisilazane; palladium diacetate; In 1,2-dimethoxyethane; at 100 ℃; for 24h;

DOI:10.1002/anie.200462629

Reference yield: 78.0%

SEC-BUTYLAMINE (33966-50-6) + 4-iodobenzoic acid (619-58-9) → 4-N-sec-butylamino-benzoic acid (518336-10-2)

Guidance literature:

With lithium hexamethyldisilazane; palladium diacetate; (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine; In 1,2-dimethoxyethane; at 100 ℃; for 48h;

DOI:10.1021/ja077074w

upstream raw materials:

SEC-BUTYLAMINE

para-chlorobenzoic acid

4-iodobenzoic acid

4-Bromobenzoic acid

Refernces

• 1、 Shen, Qilong,Shekhar, Shashank,Stambuli, James P.,Hartwig, John F.. "Highly reactive, general, and long-lived catalysts for coupling heteroaryl and aryl chlorides with primary nitrogen nucleophiles". . p. 1371 - 1375. Retrieved 2007/10/03.