3-CHLOROQUINOLIN-4-OL

Base Information

• Chemical Name: 3-CHLOROQUINOLIN-4-OL
• CAS No.: 58550-89-3
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.606
• Hs Code.: 2933499090
• Mol file: 58550-89-3.mol

Synonyms:3-CHLOROQUINOLIN-4-OL

Chemical Property of 3-CHLOROQUINOLIN-4-OL

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.641
• Boiling Point: 273.9°Cat760mmHg
• Flash Point: 119.4°C
• PSA: 33.12000
• Density: 1.38g/cm³
• LogP: 2.59380

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloroquinolin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-CHLOROQUINOLIN-4-OL

There total 1 articles about 3-CHLOROQUINOLIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-hydroxyquinoline-2-carboxylate (24782-43-2) → 3-chloro-quinolin-4-ol (58550-89-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; acetic acid anhydride; iodine; SO₂Cl₂

2: aqueous NaOH

3: diphenyl ether; biphenyl / 180 °C

With sodium hydroxide; sulfuryl dichloride; diphenylether; biphenyl; iodine; acetic anhydride; acetic acid;

DOI:10.1021/ja01216a044

Reference yield: 52.0%

3-chloro-quinolin-4-ol (58550-89-3) + diethyl phosphorochloridothioate (2524-04-1) → 3-chloro-1-ethyl-1H-quinolin-4-one (64965-21-5) + sulfotep (3689-24-5) + Thiophosphoric acid O-(3-chloro-quinolin-4-yl) ester O',O''-diethyl ester (93516-21-3)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydroxide; In tetrachloromethane; at 60 ℃; for 72h;

DOI:10.1055/s-1984-30877

Reference yield:

3-chloro-quinolin-4-ol (58550-89-3) → (3-chloro-[4]quinolyl)-phenyl-amine

Guidance literature:

Multi-step reaction with 2 steps

1: phosphoryl chloride

2: 150 - 160 °C

With trichlorophosphate;

DOI:10.1021/ja01216a044

upstream raw materials:

ethyl 4-hydroxyquinoline-2-carboxylate

Downstream raw materials:

3-chloro-1-ethyl-1H-quinolin-4-one

sulfotep

Thiophosphoric acid O-(3-chloro-quinolin-4-yl) ester O',O''-diethyl ester

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