2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde

Base Information

• Chemical Name: 2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde
• CAS No.: 32580-00-0
• Molecular Formula: C19H18 O5
• Molecular Weight: 326.349
• Hs Code.: 29400090
• NSC Number: 176981
• DSSTox Substance ID: DTXSID10306505
• Mol file: 32580-00-0.mol

Synonyms:32580-00-0;2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde;2,4:3,5-Di-O-benzylidene-aldehydo-D-ribose hydrate;NSC176981;DTXSID10306505;NSC-176981;2,4:3,5-Di-O-benzylidene-aldehydo-D-ribose;A821328;2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-carboxaldehyde;1-CYCLOPROPYL-5-AMIDO-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLICACIDETHYLESTER

Chemical Property of 2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde

Chemical Property:

• Melting Point: 147-149oC(lit.)
• Boiling Point: 490.7±45.0 °C(Predicted)
• PSA: 63.22000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 2.71800
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 326.11542367
• Heavy Atom Count: 24
• Complexity: 416

Purity/Quality:

97% ^*data from raw suppliers

2,4:3,5-Di-O-benzylidene-aldehydo-D-ribose hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C2C(C(OC(O2)C3=CC=CC=C3)C=O)OC(O1)C4=CC=CC=C4

Technology Process of 2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde

There total 1 articles about 2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(2,4:3,5-di-O-benzylidenepentitol-1-yl)pyridine (32580-00-0)

Guidance literature:

2,4;3,5-Dibenzyliden-D-ribose-mercaptal, HgCl2, HgO in sd. wss. Aceton;

Reference yield: 15.0%

2,4:3,5-di-O-benzylidene-D-ribose (32580-00-0,32580-01-1,32580-02-2,83212-63-9,93220-58-7,107436-58-8,122921-72-6,143616-89-1) + edaravone (89-25-8) → 1',1'-bis-<3-methyl-5-oxo-1-phenyl-Δ2-4-pyrazyl>-1'-deoxy-2',4':3',5'-di-O-benzylidene-D-ribitol (89243-18-5)

Guidance literature:

With ammonium acetate; In methanol; for 48h; Ambient temperature;

Reference yield:

2-(2,4:3,5-di-O-benzylidenepentitol-1-yl)pyridine (32580-00-0) → pseudouridine (1445-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) nBuLi, THF, (ii) /BRN= 1260242/

2: (i) BBr₃, THF, (ii) MeOH, CH₂Cl₂

Downstream raw materials:

3-(O²,O⁴;O³,O⁵-(Ξ,Ξ)-dibenzylidene-D-ribitol-1-ylidene)-pyrrolidine-2,5-dione

(1R)-D-O²,O⁴;O³,O⁵-(R,R)-dibenzylidene-1-(2,6-bis-benzyloxy-pyridin-3-yl)-ribitol

(1S)-D-O²,O⁴;O³,O⁵-(R,R)-dibenzylidene-1-(2,6-bis-benzyloxy-pyridin-3-yl)-ribitol

3-(O²,O⁴;O³,O⁵-(R,R)-dibenzylidene-D-ribosylidene)-1-phenyl-pyrrolidine-2,5-dione