7-FLUORO-4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 7-FLUORO-4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 476199-02-7
• Molecular Formula: C₁₁H₉FO₃S
• Molecular Weight: 240.255
• Mol file: 476199-02-7.mol

Synonyms:7-Fluoro-4-methoxy-benzo[b]thiophene-2-carboxylic acid methyl ester;

Chemical Property of 7-FLUORO-4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 358.829°C at 760 mmHg
• Flash Point: 170.814°C
• PSA: 63.77000
• Density: 1.341g/cm³
• LogP: 2.83560

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-FLUORO-4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

There total 2 articles about 7-FLUORO-4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Methyl thioglycolate (2365-48-2) + 2,3-difluoro-6-methoxybenzaldehyde (187543-87-9) → methyl 7-fluoro-4-methoxy-1-benzothiophene-2-carboxylate (476199-02-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.08.005

Reference yield:

1,2-difluoro-4-methoxy-benzene (115144-40-6) → methyl 7-fluoro-4-methoxy-1-benzothiophene-2-carboxylate (476199-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / LDA / tetrahydrofuran

2: 87 percent / Et₃N / dimethylformamide

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.08.005

Reference yield: 97.0%

methyl 7-fluoro-4-methoxy-1-benzothiophene-2-carboxylate (476199-02-7) → 7-fluoro-4-methoxy-1-benzothiophene-2-carboxylic acid (476199-03-8)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/j.bmcl.2004.08.005

upstream raw materials:

Methyl thioglycolate

2,3-difluoro-6-methoxybenzaldehyde

1,2-difluoro-4-methoxy-benzene

Downstream raw materials:

7-fluoro-4-methoxy-1-benzothiophene-2-carboxylic acid

4-(3-chloro-1-phenyl-propoxy)-7-fluoro-benzo[b]thiophene

4-(3-chloro-1-phenyl-propoxy)-7-fluoro-benzo[b]thiophene