6,10-Dioxaspiro[4.5]decan-2-one,4-ethyl-8,8-dimethyl-,(4R)-(9CI)

Base Information

Chemical Name:6,10-Dioxaspiro[4.5]decan-2-one,4-ethyl-8,8-dimethyl-,(4R)-(9CI)
CAS No.:477293-78-0
Molecular Formula:C12H20O3
Molecular Weight:0
Hs Code.:
Mol file:477293-78-0.mol

Synonyms:6,10-Dioxaspiro[4.5]decan-2-one,4-ethyl-8,8-dimethyl-,(4R)-(9CI)

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Chemical Property of 6,10-Dioxaspiro[4.5]decan-2-one,4-ethyl-8,8-dimethyl-,(4R)-(9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of 6,10-Dioxaspiro[4.5]decan-2-one,4-ethyl-8,8-dimethyl-,(4R)-(9CI)

There total 3 articles about 6,10-Dioxaspiro[4.5]decan-2-one,4-ethyl-8,8-dimethyl-,(4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 557-20-0
diethylzinc

: 129822-78-2
8,8-dimethyl-6,10-dioxa-spiro[4.5]dec-3-en-2-one

: 477293-78-0
4-ethyl-8,8-dimethyl-6,10-dioxaspiro[4.5]decan-2-one

: 4-ethyl-3-(2-hydroxy-8,8-dimethyl-6,10-dioxaspiro[4.5]dec-3-en-2-yl)-8,8-dimethyl-6,10-dioxaspiro[4.5]decan-2-one

: 4-ethyl-3-(2-hydroxy-8,8-dimethyl-6,10-dioxaspiro[4.5]dec-3-en-2-yl)-8,8-dimethyl-6,10-dioxaspiro[4.5]decan-2-one

Guidance literature:: With (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-[(1R)-1-phenethyl]amine; copper(II) bis(trifluoromethanesulfonate); In toluene; at -45 ℃; for 18h;
DOI:10.1021/jo025987x

Reference yield:

: 930-60-9
maleic anhydride

: 477293-78-0
4-ethyl-8,8-dimethyl-6,10-dioxaspiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / BF₃*Et₂O / CHCl₃ / 1.5 h / 0 °C

2: Cu(OTf)2; (S)-1,1'-binaphthyl-2,2'-dioxy(=P-N((R)-CH(CH₃)Ph)2) / toluene / 18 h / -45 °C

With (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-[(1R)-1-phenethyl]amine; boron trifluoride diethyl etherate; copper(II) bis(trifluoromethanesulfonate); In chloroform; toluene;
DOI:10.1021/jo025987x

Reference yield:

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 477293-78-0
4-ethyl-8,8-dimethyl-6,10-dioxaspiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / BF₃*Et₂O / CHCl₃ / 1.5 h / 0 °C

2: Cu(OTf)2; (S)-1,1'-binaphthyl-2,2'-dioxy(=P-N((R)-CH(CH₃)Ph)2) / toluene / 18 h / -45 °C

With (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-[(1R)-1-phenethyl]amine; boron trifluoride diethyl etherate; copper(II) bis(trifluoromethanesulfonate); In chloroform; toluene;
DOI:10.1021/jo025987x