Thieno[2,3-c]pyridine-2-carboxylic acid (9CI)

Base Information

• Chemical Name: Thieno[2,3-c]pyridine-2-carboxylic acid (9CI)
• CAS No.: 478149-00-7
• Molecular Formula: C8H5NO2S
• Molecular Weight: 179.199
• Hs Code.: 2934999090
• Mol file: 478149-00-7.mol

Synonyms:Thieno[2,3-c]pyridine-2-carboxylic acid (9CI)

Chemical Property of Thieno[2,3-c]pyridine-2-carboxylic acid (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.732
• Boiling Point: 418.262°C at 760 mmHg
• Flash Point: 206.758°C
• PSA: 78.43000
• Density: 1.509g/cm³
• LogP: 1.99450
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Thieno[2,3-c]pyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Thieno[2,3-c]pyridine-2-carboxylic Acid is used in the preparation of inhibitors such as BET bromodomain inhibitors.

Technology Process of Thieno[2,3-c]pyridine-2-carboxylic acid (9CI)

There total 7 articles about Thieno[2,3-c]pyridine-2-carboxylic acid (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl thieno[2,3-c]pyridine-2-carboxylate (870243-58-6) → thieno[2,3-c]pyridine-2-carboxylic acid (478149-00-7)

Guidance literature:

With water; sodium hydroxide; at 20 - 25 ℃; for 1h;

Reference yield: 38.0%

ethyl thieno[2,3-c]pyridine-2-carboxylate (478148-99-1) → thieno[2,3-c]pyridine-2-carboxylic acid (478149-00-7)

Guidance literature:

With sodium hydroxide; In methanol; water;

Reference yield: 38.0%

→ thieno[2,3-c]pyridine-2-carboxylic acid (478149-00-7)

Guidance literature:

upstream raw materials:

ethyl thieno[2,3-c]pyridine-2-carboxylate

3,5-dibromopyridine

3,5-dibromopyridine-4-carboxaldehyde

4-bromo-thieno<2,3-c>pyridine-2-carboxylic acid methyl ester

Downstream raw materials:

thieno[2,3-c]pyridine-2-carboxylic acid 4-(morpholine-4-sulfonyl)-benzylamide

N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2-carboxamide