2H-1,2-Oxazine-4,5-diol, tetrahydro-6-(hydroxymethyl)-, (4R,5S,6R)- (9CI)

Base Information

Chemical Name:2H-1,2-Oxazine-4,5-diol, tetrahydro-6-(hydroxymethyl)-, (4R,5S,6R)- (9CI)
CAS No.:478175-48-3
Molecular Formula:C₅H₁₁NO₄
Molecular Weight:149.147
Hs Code.:
Mol file:478175-48-3.mol

Synonyms:2H-1,2-Oxazine-4,5-diol, tetrahydro-6-(hydroxymethyl)-, (4R,5S,6R)- (9CI)

Suppliers and Price of 2H-1,2-Oxazine-4,5-diol, tetrahydro-6-(hydroxymethyl)-, (4R,5S,6R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2H-1,2-Oxazine-4,5-diol, tetrahydro-6-(hydroxymethyl)-, (4R,5S,6R)- (9CI)

Chemical Property:

Melting Point:149 - 151 °C (ethyl acetate)
PSA：81.95000
LogP:-2.06730

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2H-1,2-Oxazine-4,5-diol, tetrahydro-6-(hydroxymethyl)-, (4R,5S,6R)- (9CI)

There total 10 articles about 2H-1,2-Oxazine-4,5-diol, tetrahydro-6-(hydroxymethyl)-, (4R,5S,6R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 478175-50-7
(4R,5S,6R)-5,6-dihydro-4,5-dihydroxy-6-hydroxymethyl-4H-1,2-oxazine

: 478175-48-3,226081-40-9,226081-48-7,226081-50-1
(4R,5S,6R)-4,5-dihydroxy-6-hydroxymethyl-3,4,5,6-tetrahydro-2H-1,2-oxazine

Guidance literature:: With sodium cyanoborohydride; In acetic acid; at 20 ℃; for 0.666667h;
DOI:10.1139/v02-060

Reference yield:

: 478175-99-4
benzyl β-L-xylopyranoside

: 478175-48-3,226081-40-9,226081-48-7,226081-50-1
(4R,5S,6R)-4,5-dihydroxy-6-hydroxymethyl-3,4,5,6-tetrahydro-2H-1,2-oxazine

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / hydrogen chloride / methanol; dimethylformamide / 1 h / 20 °C

2: 68 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

3: 1.2 g / hydrazine hydrate / CHCl₃

4: triethylamine / CHCl₃ / Heating

5: 984 mg / pyridinium p-toluenesulfonate / methanol; CHCl₃ / 1 h / Heating

6: 94 percent / H₂; 1 M hydrochloric acid / 10 percent Pd/C / H₂O; tetrahydrofuran / 24 h / 760 Torr

7: 72 mg / H₂O / 0.17 h / Heating

8: 160 mg / NaCNBH₃ / acetic acid / 0.67 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; pyridinium p-toluenesulfonate; sodium cyanoborohydride; hydrazine hydrate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water; acetic acid; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1139/v02-060

Reference yield:

: 478175-66-5
benzyl 2,3-O-isopropylidene-β-L-xylopyranoside

: 478175-48-3,226081-40-9,226081-48-7,226081-50-1
(4R,5S,6R)-4,5-dihydroxy-6-hydroxymethyl-3,4,5,6-tetrahydro-2H-1,2-oxazine

Guidance literature:: Multi-step reaction with 7 steps

1: 68 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

2: 1.2 g / hydrazine hydrate / CHCl₃

3: triethylamine / CHCl₃ / Heating

4: 984 mg / pyridinium p-toluenesulfonate / methanol; CHCl₃ / 1 h / Heating

5: 94 percent / H₂; 1 M hydrochloric acid / 10 percent Pd/C / H₂O; tetrahydrofuran / 24 h / 760 Torr

6: 72 mg / H₂O / 0.17 h / Heating

7: 160 mg / NaCNBH₃ / acetic acid / 0.67 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; pyridinium p-toluenesulfonate; sodium cyanoborohydride; hydrazine hydrate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water; acetic acid; 1: Mitsunobu reaction;
DOI:10.1139/v02-060